Results 21 to 30 of about 13,075 (222)
Frontiers in Immunology, 2022 A series of HIV-1 CRF01_AE/CRF07_BC recombinants were previously found to have emerged gradually in a superinfected patient (patient LNA819). However, the extent to which T-cell responses influenced the development of these recombinants after ...
Hui Zhang +30 more
doaj +1 more source
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. [PDF]
PLoS Pathogens, 2007 Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways.
Zabrina L Brumme +16 more
doaj +1 more source
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]
, 2013 G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO +36 more
core +1 more source
HIV-1 Nef mediates caspase activation for viral release.
, 2023 (A) RNAseq analyses for differential gene expression on highlighted gene groups responsible for the cellular signaling pathways leading to caspase activation and apoptosis. RNA sequencing were performed using day 6 Nef+ and Nef- HIV-1NL4-3 infected CD4 T
Julianna Buchwald (14608810) +9 more
core +1 more source
Retrovirology, 2008 AIDS-associated, CCR5-tropic (R5) HIV-1 clones, isolated from a patient that never developed CXCR4-tropic HIV-1, replicate to a greater extent and cause greater cytopathic effects than R5 HIV-1 clones isolated before the onset of AIDS.
Rekosh David +7 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2021 Osteoporosis is characterized by osteopenia and bone tissue microstructure degradation. Adipose‐derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells and have the potential to undergo ...
Ying Ming, Zheng‐Peng Liu
doaj +1 more source
Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes
Medical Laboratory Journal, 2021 Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar +3 more
doaj
Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children. [PDF]
PLoS ONE, 2015 Disease progression varies among HIV-1-infected individuals. The present study aimed to explore possible viral and host factors affecting disease progression in HIV-1-infected children.Since 2000, 102 HIV-1 vertically-infected children have been followed-
Matilda Chelimo Saina +10 more
doaj +1 more source
Journal of Ginseng Research, 2021 Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1–infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs. Methods:
Young Keol Cho, Jung-Eun Kim
doaj +1 more source
Characterization of the Cutaneous Exanthem in Macaques Infected with a Nef Gene Variant of SIVmac239 [PDF]
Journal of Investigative Dermatology, 1998 The molecularly cloned viruses known as SIVmac239/R17Y and SIVmac239/YEnef cause extensive lymphocyte activation and induce an acute disease syndrome in macaque monkeys. One manifestation of this syndrome is a severe diffuse cutaneous maculopapular exanthem that is similar to the exanthem associated with HIV-1 infection.
Sasseville, Vito G. +7 more
openaire +2 more sources