Results 21 to 30 of about 12,393 (180)

Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children. [PDF]

PLoS ONE, 2015
Disease progression varies among HIV-1-infected individuals. The present study aimed to explore possible viral and host factors affecting disease progression in HIV-1-infected children.Since 2000, 102 HIV-1 vertically-infected children have been followed-
Matilda Chelimo Saina, Xiuqiong Bi, Raphael Lihana, Raphael Lwembe, Azumi Ishizaki, Annie Panikulam, Tresa Palakudy, Rachel Musoke, Mary Owens, Elijah Maritim Songok, Hiroshi Ichimura   +10 more
doaj   +1 more source

The frequency of defective genes in vif and vpr genes in 20 hemophiliacs is associated with Korean Red Ginseng and highly active antiretroviral therapy: the impact of lethal mutations in vif and vpr genes on HIV-1 evolution

Journal of Ginseng Research, 2021
Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1–infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs. Methods:
Young Keol Cho, Jung-Eun Kim
doaj   +1 more source

Characterization of the Cutaneous Exanthem in Macaques Infected with a Nef Gene Variant of SIVmac239 [PDF]

Journal of Investigative Dermatology, 1998
The molecularly cloned viruses known as SIVmac239/R17Y and SIVmac239/YEnef cause extensive lymphocyte activation and induce an acute disease syndrome in macaque monkeys. One manifestation of this syndrome is a severe diffuse cutaneous maculopapular exanthem that is similar to the exanthem associated with HIV-1 infection.
Sasseville, Vito G., Veazey, Ronald, Knight, Heather L., Caunt, Diane, Lackner, Andrew A., Rottman, James B., Du, Zhenjian, Desrosiers, Ronald C.   +7 more
openaire   +2 more sources

Effects of HIV-1 nef on cellular gene expression profiles

Journal of Biomedical Science, 2002
The early human immunodeficiency virus (HIV) accessory protein Nef makes an important contribution to virulence, but the mechanisms by which Nef influences pathogenesis remain unclear. Many well-studied effects of Nef, like CD4 and class I MHC downregulation, occur posttranslationally.
Syed, Shaheduzzaman, Vyjayanthi, Krishnan, Ana, Petrovic, Michael, Bittner, Paul, Meltzer, Jeffrey, Trent, Sundararajan, Venkatesan, Steven, Zeichner   +7 more
openaire   +2 more sources

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

mBio, 2016
HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells.
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno   +10 more
doaj   +1 more source

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Retrovirology, 2018
Background Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences.
Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Sylvia Lopes Maia Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Monick Lindenmeyer Guimarães, Mariza Gonçalves Morgado   +8 more
doaj   +1 more source

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

Cell Reports, 2015
NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation.
Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff   +13 more
doaj   +1 more source

Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Memorias do Instituto Oswaldo Cruz, 2002
Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
ML Guimarães, AS Moreira, MG Morgado
doaj   +1 more source

HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis [PDF]

Journal of the American Society of Nephrology, 2006
This study aimed to identify the causative gene for HIV-1 associated nephropathy, a paradigmatic podocytopathy. A previous study demonstrated that transgenic expression of nonstructural HIV-1 genes selectively in podocytes in mice with FVB/N genetic background resulted in podocyte injury and glomerulosclerosis.
Yiqin, Zuo, Taiji, Matsusaka, Jianyong, Zhong, Ji, Ma, Li-jun, Ma, Zaher, Hanna, Paul, Jolicoeur, Agnes B, Fogo, Iekuni, Ichikawa   +8 more
openaire   +2 more sources

Nef gene evolution from a single transmitted strain in acute SIV infection [PDF]

Retrovirology, 2009
Abstract Background The acute phase of immunodeficiency virus infection plays a crucial role in determining steady-state virus load and subsequent progression of disease in both humans and nonhuman primates. The acute period is also the time when vaccine-mediated effects on host immunity are likely to exert their ...
Bimber, BN, Chugh, P, Giorgi, EE, Kim, B, Almudevar, AL, Dewhurst, S, O'Connor, DH, Lee, HY   +7 more
openaire   +3 more sources