Results 21 to 30 of about 1,695,057 (181)

S10_S17_Data from Nef et al.

, 2022
Supplementary Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". S10 Data.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

mBio, 2016
HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells.
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno   +10 more
doaj   +1 more source

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Retrovirology, 2018
Background Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences.
Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Sylvia Lopes Maia Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Monick Lindenmeyer Guimarães, Mariza Gonçalves Morgado   +8 more
doaj   +1 more source

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

Cell Reports, 2015
NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation.
Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff   +13 more
doaj   +1 more source

Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Memorias do Instituto Oswaldo Cruz, 2002
Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
ML Guimarães, AS Moreira, MG Morgado
doaj   +1 more source

Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses [PDF]

, 2010
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1
McKinnon, E., Rebecca Laird, Chopra, A., John, M., Simon Mallal, Almeida, C.M., Keane, N.M., Abha Chopra, David Heckerman, Heckerman, D., Imran Ahmad, Coral-Ann M. Almeida, Elizabeth McKinnon, Carl Kadie, Roberts, S.G., Mina John, Kadie, C., Niamh M. Keane, Laird, R., Steven G. Roberts, Ahmad, I., Mallal, S.   +21 more
core   +1 more source

HIV-1 Nef mediates caspase activation for viral release.

, 2023
(A) RNAseq analyses for differential gene expression on highlighted gene groups responsible for the cellular signaling pathways leading to caspase activation and apoptosis. RNA sequencing were performed using day 6 Nef+ and Nef- HIV-1NL4-3 infected CD4 T
Julianna Buchwald (14608810), Tae-Wook Chun (73430), Zhongcheng Zou (206247), Joanna Ireland (14608804), Thomas J. Shen (14608813), Susan Moir (73428), Gwynne Roth (14608807), Jason Segura (14608801), Elizabeth Fischer (179885), Peter D. Sun (8977886)   +9 more
core   +1 more source

S8_Data from Nef et al.

, 2022
S8 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". (A) Pairwise FST values of ARC_116.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells

Vaccine Research, 2020
Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani, Fatemeh Rouhollah, Maryam Naseroleslami, Azam Bolhassani   +3 more
doaj  

Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors

Retrovirology, 2010
Elite controllers or suppressors (ES) are HIV-1 infected patients who maintain viral loads of < 50 copies/ml without antiretroviral therapy. CD8+ T cells are thought to play a key role in the control of viral replication and exert selective pressure on ...
Siliciano Robert F, Ray Stuart C, Bailey Justin R, O'Connell Karen A, Brennan Timothy P, Salgado Maria, Blankson Joel N   +6 more
doaj   +1 more source