Results 11 to 20 of about 1,695,057 (181)

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity [PDF]

, 2013
G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome.
NADAI, MATTEO, PALU', GIORGIO, Qiu, Jianming, Smithgall, TE, Jerrod A Poe, J. A. Poe, Palumbo, M, Matteo Nadai, Ilaria Frasson, Poe, Jerrod A., Giorgio Palù, RICHTER, SARA, T. E. Smithgall, Poe, JA, Frasson Ilaria, Poe Jerrod A., Palù, Giorgio, Smithgall, Thomas E., Sara N Richter, Rosalba Perrone, Nadai, M, Palumbo Manlio, Richter, Sara N., Manlio Palumbo, Richter Sara N., Palù, G, Perrone, R, Richter, SN, Smithgall Thomas E., Palù Giorgio, Thomas E Smithgall, PERRONE, ROSALBA, Frasson, I, Nadai Matteo, FRASSON, ILARIA, PALUMBO, MANLIO, Perrone Rosalba   +36 more
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Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells [PDF]

, 2007
Background Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components.
Buriani, Giampaolo, Nuttall, James, Marusic Carla, Lombardi Raffaele, Lombardi, Raffaele, Baschieri , Selene, Buriani Giampaolo, Eugenio Benvenuto, Lico Chiara, Baschieri Selene, Frigerio, Lorenzo, James Nuttall, Benvenuto Eugenio, Lorenzo Frigerio, Nuttall James, Giampaolo Buriani, Marusic, Carla, Selene Baschieri, Frigerio Lorenzo, Raffaele Lombardi, Benvenuto, Eugenio, Chiara Lico, Carla Marusic, Lico, Chiara   +23 more
core   +1 more source

Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142

Retrovirology, 2008
AIDS-associated, CCR5-tropic (R5) HIV-1 clones, isolated from a patient that never developed CXCR4-tropic HIV-1, replicate to a greater extent and cause greater cytopathic effects than R5 HIV-1 clones isolated before the onset of AIDS.
Rekosh David, Hammarskjöld Marie-Louise, Alexander Melissa A, Powell Maria LC, Broderick Brooks, Scoggins Robert M, Olivieri Kevin C, Camerini David   +7 more
doaj   +1 more source

Overexpression of lncRNA‐NEF regulates the miR‐155/PTEN axis to inhibit adipogenesis and promote osteogenesis

Kaohsiung Journal of Medical Sciences, 2021
Osteoporosis is characterized by osteopenia and bone tissue microstructure degradation. Adipose‐derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells and have the potential to undergo ...
Ying Ming, Zheng‐Peng Liu
doaj   +1 more source

Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes

Medical Laboratory Journal, 2021
Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar, Azam Bolhassani, Fatemeh Rouhollah, Masoumeh Heshmati   +3 more
doaj  

Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children. [PDF]

PLoS ONE, 2015
Disease progression varies among HIV-1-infected individuals. The present study aimed to explore possible viral and host factors affecting disease progression in HIV-1-infected children.Since 2000, 102 HIV-1 vertically-infected children have been followed-
Matilda Chelimo Saina, Xiuqiong Bi, Raphael Lihana, Raphael Lwembe, Azumi Ishizaki, Annie Panikulam, Tresa Palakudy, Rachel Musoke, Mary Owens, Elijah Maritim Songok, Hiroshi Ichimura   +10 more
doaj   +1 more source

The frequency of defective genes in vif and vpr genes in 20 hemophiliacs is associated with Korean Red Ginseng and highly active antiretroviral therapy: the impact of lethal mutations in vif and vpr genes on HIV-1 evolution

Journal of Ginseng Research, 2021
Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1–infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs. Methods:
Young Keol Cho, Jung-Eun Kim
doaj   +1 more source

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. [PDF]

, 2015
To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Rudolph, Jochen M, Veronica Briz, Muñoz-Fernandez, Maria Angeles, Marta Martínez-Bonet (527145), Fackler, Oliver T, Madrid González, Ricardo, Jochen M. Rudolph (839776), Rudolph, Jochen M., Jochen M Rudolph, Briz, Veronica, Miguel Relloso, Maria Angeles Muñoz-Fernandez, Martínez-Bonet, Marta, Oliver T Fackler, Oliver T. Fackler (36453), Claudia Palladino (500189), Ricardo Madrid (373696), Marta Martínez-Bonet, Veronica Briz (5666269), Relloso, Miguel, Claudia Palladino, Ricardo Madrid, Madrid, Ricardo, Maria Angeles Muñoz-Fernandez (5666272), Palladino, Claudia, Fackler, Oliver T., Miguel Relloso (839777)   +26 more
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S6_Data from Nef et al.

, 2022
S6 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros".
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source