Results 11 to 20 of about 12,393 (180)

A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef. [PDF]

PLoS ONE, 2015
The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a process that requires the host proteins clathrin and AP-1. To identify other proteins involved
Maja K Choma, Jennifer Lumb, Patrycja Kozik, Margaret S Robinson   +3 more
doaj   +1 more source

Genealogical Evidence for Positive Selection in the nef Gene of HIV-1 [PDF]

Genetics, 1999
AbstractThe pattern and process of evolution in the nef gene of HIV-1 was analyzed within and among patients. Using a maximum likelihood method that allows for variable intensity of selection pressure among codons, strong positive selection was detected in a hemophiliac patient over 30 mo of infection.
P M, Zanotto, E G, Kallas, R F, de Souza, E C, Holmes   +3 more
openaire   +2 more sources

Mutational analysis of the simian immunodeficiency virus SIVmac nef gene [PDF]

Journal of Virology, 1991
We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gene, as this gene is a candidate gene
D, Binninger, J, Ennen, D, Bonn, S G, Norley, R, Kurth   +4 more
openaire   +2 more sources

HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability

Infectious Agents and Cancer, 2020
Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy.
Nontlantla Mdletshe, Andrew Nel, Karen Shires, Shaheen Mowla   +3 more
doaj   +1 more source

HIV-1–Specific Immunodominant T-Cell Responses Drive the Dynamics of HIV-1 Recombination Following Superinfection

Frontiers in Immunology, 2022
A series of HIV-1 CRF01_AE/CRF07_BC recombinants were previously found to have emerged gradually in a superinfected patient (patient LNA819). However, the extent to which T-cell responses influenced the development of these recombinants after ...
Hui Zhang, Hui Zhang, Hui Zhang, Shuang Cao, Shuang Cao, Shuang Cao, Shuang Cao, Yang Gao, Yang Gao, Yang Gao, Xiao Sun, Xiao Sun, Xiao Sun, Fanming Jiang, Fanming Jiang, Fanming Jiang, Bin Zhao, Bin Zhao, Bin Zhao, Haibo Ding, Haibo Ding, Haibo Ding, Tao Dong, Tao Dong, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Hong Shang, Hong Shang, Hong Shang, Hong Shang   +30 more
doaj   +1 more source

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. [PDF]

PLoS Pathogens, 2007
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways.
Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P Richard Harrigan   +16 more
doaj   +1 more source

Glomerulosclerosis and viral gene expression in HIV-transgenic mice: Role of nef [PDF]

Kidney International, 2000
Human immunodeficiency virus (HIV)-associated nephropathy is characterized by focal segmental glomerulosclerosis and microcystic tubular dilation. We have previously described a mouse transgenic for a Deltagag-pol HIV-1 genome, which develops glomerulosclerosis, cutaneous papillomas, and cataracts.We developed mice transgenic for a Deltagag-pol-nef HIV
Kajiyama, Wataru, Kopp, Jeffrey B., Marinos, Nancy J., Klotman, Paul E., Dickie, Peter   +4 more
openaire   +2 more sources

Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142

Retrovirology, 2008
AIDS-associated, CCR5-tropic (R5) HIV-1 clones, isolated from a patient that never developed CXCR4-tropic HIV-1, replicate to a greater extent and cause greater cytopathic effects than R5 HIV-1 clones isolated before the onset of AIDS.
Rekosh David, Hammarskjöld Marie-Louise, Alexander Melissa A, Powell Maria LC, Broderick Brooks, Scoggins Robert M, Olivieri Kevin C, Camerini David   +7 more
doaj   +1 more source

Overexpression of lncRNA‐NEF regulates the miR‐155/PTEN axis to inhibit adipogenesis and promote osteogenesis

Kaohsiung Journal of Medical Sciences, 2021
Osteoporosis is characterized by osteopenia and bone tissue microstructure degradation. Adipose‐derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells and have the potential to undergo ...
Ying Ming, Zheng‐Peng Liu
doaj   +1 more source

Construction of a Prokaryotic Expression Vector harboring Two HIV-1 Accessory Genes

Medical Laboratory Journal, 2021
Background and objectives: HIV-1 Nef and Vpr antigens have been described as suitable candidates for therapeutic HIV vaccine development. The aim of this study was to generate Nef-Vpr fusion gene construct and to clone the construct into pET-23a (+), a ...
Arash Nikyar, Azam Bolhassani, Fatemeh Rouhollah, Masoumeh Heshmati   +3 more
doaj