Results 11 to 20 of about 13,075 (222)

HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis [PDF]

Journal of the American Society of Nephrology, 2006
This study aimed to identify the causative gene for HIV-1 associated nephropathy, a paradigmatic podocytopathy. A previous study demonstrated that transgenic expression of nonstructural HIV-1 genes selectively in podocytes in mice with FVB/N genetic background resulted in podocyte injury and glomerulosclerosis.
Yiqin, Zuo, Taiji, Matsusaka, Jianyong, Zhong, Ji, Ma, Li-jun, Ma, Zaher, Hanna, Paul, Jolicoeur, Agnes B, Fogo, Iekuni, Ichikawa   +8 more
openaire   +3 more sources

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo [PDF]

Journal of Virology, 1993
The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corresponding protein sequences of ...
D C, Shugars, M S, Smith, D H, Glueck, P V, Nantermet, F, Seillier-Moiseiwitsch, R, Swanstrom   +5 more
openaire   +4 more sources

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years

Journal of Ginseng Research, 2017
Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho, Jung-Eun Kim, Jun-Hee Woo   +2 more
doaj   +3 more sources

Glomerulosclerosis and viral gene expression in HIV-transgenic mice: Role of nef [PDF]

Kidney International, 2000
Human immunodeficiency virus (HIV)-associated nephropathy is characterized by focal segmental glomerulosclerosis and microcystic tubular dilation. We have previously described a mouse transgenic for a Deltagag-pol HIV-1 genome, which develops glomerulosclerosis, cutaneous papillomas, and cataracts.We developed mice transgenic for a Deltagag-pol-nef HIV
Kajiyama, Wataru, Kopp, Jeffrey B., Marinos, Nancy J., Klotman, Paul E., Dickie, Peter   +4 more
openaire   +3 more sources

Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors

Retrovirology, 2010
Elite controllers or suppressors (ES) are HIV-1 infected patients who maintain viral loads of < 50 copies/ml without antiretroviral therapy. CD8+ T cells are thought to play a key role in the control of viral replication and exert selective pressure on ...
Siliciano Robert F, Ray Stuart C, Bailey Justin R, O'Connell Karen A, Brennan Timothy P, Salgado Maria, Blankson Joel N   +6 more
doaj   +2 more sources

nef gene sequence variation among HIV‐1‐infected African children^*

HIV Medicine, 2006
BackgroundThere are few data on African children infected with nonclade B HIV‐1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV‐1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in ...
Chakraborty, R, Reinis, M, Rostron, T, Philpott, S, Dong, T, D'Agostino, A, Musoke, R, Silva, E, Stumpf, M, Weiser, B, Burger, H, Rowland-Jones, S   +11 more
openaire   +4 more sources

Single Genome Sequencing of Expressed and Proviral HIV-1 Envelope Glycoprotein 120 (gp120) and nef Genes [PDF]

Bio-Protocol, 2017
The current study provides detailed protocols utilized to amplify the complete HIV-1 gp120 and nef genes from single copies of expressed or integrated HIV present in fresh-frozen autopsy tissues of patients who died while on combined antiretroviral ...
David Nolan, Susanna Lamers, Rebecca Rose, James Dollar, Marco Salemi, Michael McGrath   +5 more
doaj   +2 more sources

The nef gene of simian immunodeficiency virus SIVmac1A11 [PDF]

Journal of Virology, 1992
The role of the simian immunodeficiency virus (SIV) nef gene in viral replication was investigated in several tissue culture systems. SIVmac1A11 is a molecularly cloned virus which replicates in both peripheral blood mononuclear cells (PBMC) and macrophages, although no disease is observed in infected rhesus macaques.
R E, Unger, M L, Marthas, E, Pratt-Lowe, P A, Padrid, P A, Luciw   +4 more
openaire   +2 more sources

Genealogical Evidence for Positive Selection in the nef Gene of HIV-1 [PDF]

Genetics, 1999
AbstractThe pattern and process of evolution in the nef gene of HIV-1 was analyzed within and among patients. Using a maximum likelihood method that allows for variable intensity of selection pressure among codons, strong positive selection was detected in a hemophiliac patient over 30 mo of infection.
P M, Zanotto, E G, Kallas, R F, de Souza, E C, Holmes   +3 more
openaire   +2 more sources

Mutational analysis of the simian immunodeficiency virus SIVmac nef gene [PDF]

Journal of Virology, 1991
We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gene, as this gene is a candidate gene
D, Binninger, J, Ennen, D, Bonn, S G, Norley, R, Kurth   +4 more
openaire   +2 more sources