Results 21 to 30 of about 5,248,714 (172)

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef

Retrovirology, 2011
Background A new subgroup of HIV-1, designated Group P, was recently detected in two unrelated patients of Cameroonian origin. HIV-1 Group P phylogenetically clusters with SIVgor suggesting that it is the result of a cross-species transmission from ...
Sauter Daniel, Hué Stéphane, Petit Sarah J, Plantier Jean-Christophe, Towers Greg J, Kirchhoff Frank, Gupta Ravindra K   +6 more
doaj   +1 more source

nef Gene Is Required for Robust Productive Infection by Simian Immunodeficiency Virus of T-Cell-Rich Paracortex in Lymph Nodes [PDF]

Journal of Virology, 2003
ABSTRACT The pathogenesis of AIDS virus infection in a nonhuman primate AIDS model was studied by comparing plasma viral loads, CD4 + T-cell subpopulations in peripheral blood mononuclear cells, and simian immunodeficiency virus (SIV) infection in lymph nodes for rhesus macaques infected with a pathogenic ...
Chie, Sugimoto, Kei, Tadakuma, Isao, Otani, Takashi, Moritoyo, Hirofumi, Akari, Fumiko, Ono, Yasuhiro, Yoshikawa, Tetsutaro, Sata, Shuji, Izumo, Kazuyasu, Mori   +9 more
openaire   +2 more sources

Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product

Journal of General Virology, 1994
During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin, M, Fauchon, A, Darveau, J A, Levy   +3 more
openaire   +2 more sources

Simian immunodeficiency virus Nef gene regulates the production of 2-LTR circles in vivo

Virology, 2003
The replication dynamics of simian immunodeficiency virus (SIVmac32H-C8), attenuated through discrete genetic disruption of the nef gene, were compared with the wild-type parental clone (SIVmac32H-J5) using quantitative molecular methods. The primary viraemia of both infections were similar during the first week, but peaked on Day 10 at higher levels ...
Clarke, S, Almond, N, Berry, N
openaire   +2 more sources

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Disease Models & Mechanisms, 2019
Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN ...
Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma   +9 more
doaj   +1 more source

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. [PDF]

, 2015
To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef.
Rudolph, Jochen M, Veronica Briz, Muñoz-Fernandez, Maria Angeles, Marta Martínez-Bonet (527145), Fackler, Oliver T, Madrid González, Ricardo, Jochen M. Rudolph (839776), Rudolph, Jochen M., Jochen M Rudolph, Briz, Veronica, Miguel Relloso, Maria Angeles Muñoz-Fernandez, Martínez-Bonet, Marta, Oliver T Fackler, Oliver T. Fackler (36453), Claudia Palladino (500189), Ricardo Madrid (373696), Marta Martínez-Bonet, Veronica Briz (5666269), Relloso, Miguel, Claudia Palladino, Ricardo Madrid, Madrid, Ricardo, Maria Angeles Muñoz-Fernandez (5666272), Palladino, Claudia, Fackler, Oliver T., Miguel Relloso (839777)   +26 more
core   +1 more source

Calcitonin gene products and the kidney [PDF]

, 1989
Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R.
core   +1 more source

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

Retrovirology, 2009
Human immunodeficiency virus type 1 (HIV-1) has been shown to replicate productively in cells of the monocyte-macrophage lineage, although replication occurs to a lesser extent than in infected T cells.
Shah Sonia, Kilareski Evelyn M, Nonnemacher Michael R, Wigdahl Brian   +3 more
doaj   +1 more source

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. [PDF]

, 1993
The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain.
Nantermet, Pascale V., Seillier-Moiseiwitsch, Francoise, Glueck, Deborah H., Shugars, Diana C., Smith, Marilyn S., Swanstrom, Ronald   +5 more
core   +1 more source

HIV-1 expression induces cyclin D₁ expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy

BMC Microbiology, 2002
Background The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium ...
Husain Mohammad, Sunamoto Masaaki, Nelson Peter J, Gelman Irwin H   +3 more
doaj   +1 more source