Results 51 to 60 of about 268,817 (310)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]

, 2009
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E., Mau, Bob, Perna, Nicole T.   +2 more
core  

A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.) [PDF]

, 2019
An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical ...
Agostinelli, C., Ambrosio, M. R., Ascani, S., Carbone, A., Di Napoli, A., Facchetti, F., Lazzi, S., Leoncini, L., Lucioni, M., Novero, D., Paulli, M., Pileri, S., Ponzoni, M., Remotti, D., Ruco, L., Sabattini, E., Tripodo, C., Zamo, A.   +17 more
core   +2 more sources

The reverse TRBV30 gene of mammals: a defect or superiority in evolution?

BMC Genomics
At the 3’ end of the C2 gene in the mammalian TRB locus, a distinct reverse TRBV30 gene (named TRBV31 in mice) has been conserved throughout evolution.
Fengli Wu, Yingjie Wu, Yuanning Yao, Yuanyuan Xu, Qi Peng, Long Ma, Jun Li, Xinsheng Yao   +7 more
doaj   +1 more source

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells

Frontiers in Immunology, 2018
To date there has not been a study directly comparing relative Igκ rearrangement frequencies obtained from genomic DNA (gDNA) and cDNA and since each approach has potential biases, this is an important issue to clarify.
Eden Kleiman, Salvatore Loguercio, Ann J. Feeney   +2 more
doaj   +1 more source

NR4A3 (NOR-1) Immunostaining Shows Better Performance than DOG1 Immunostaining in Acinic Cell Carcinoma of Salivary Gland: a Preliminary Study

eJournal of Oral Maxillofacial Research, 2021
Objectives: Acinic cell carcinoma of salivary gland harbours recurrent and specific chromosomal rearrangement [t(4;9)(q13;q31)], resulting in the translocation of secretory calcium-binding phosphoprotein gene cluster at 4q13 to nuclear receptor subfamily
Adepitan Owosho, Donald Tyler, Olufunlola Adesina, Oluwole Odujoko, Kurt Summersgill   +4 more
doaj   +1 more source

Common Gene Rearrangements in Prostate Cancer [PDF]

Journal of Clinical Oncology, 2011
Prostate cancer is a common heterogeneous disease, and most patients diagnosed in the post prostate-specific antigen (PSA) era present with clinically localized disease, the majority of which do well regardless of treatment regimen undertaken. Overall, those with advanced prostate cancer at time of diagnosis do poorly after androgen withdrawal therapy.
Christopher G. Maher, Mark A. Rubin, Arul M. Chinnaiyan   +2 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component

Chronic Diseases and Translational Medicine, 2023
Background The differential diagnosis of mucoepidermoid carcinoma (MEC) from neoplasm undergoing mucinous features brings more pitfalls to pathologists.
Yuelu Zhu, Yan Li, Lei Guo, Wenbin Li, Jiali Mu, Haifeng Zhang, Xin Li, Jianming Ying, Haizhen Lu   +8 more
doaj   +1 more source