Results 51 to 60 of about 6,798,395 (302)
Zhongliu Fangzhi YanjiuObjective To investigate the clonal rearrangement characteristics and clinical application value of IGH gene in B-cell non-Hodgkin’s lymphoma (B-NHL). Methods Demographic and clinical data as well as IGH sequencing results of 55 patients with B-NHL who ...
MA Qiang +6 more
doaj +1 more source
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma +2 more
doaj +1 more source
Chromosomal rearrangements and transposable elements in locally adapted island Drosophila [PDF]
arXiv, 2021 Chromosomal rearrangements, particularly those mediated by transposable elements (TEs), can drive adaptive evolution by creating chimeric genes, inducing de novo gene formation, or altering gene expression. Here, we investigate rearrangements evolutionary role during habitat shifts in two locally adapted populations, Drosphila santomea and Drosphila ...
arxiv
VH replacement in rearranged immunoglobulin genes [PDF]
, 2005 Examples suggesting that all or part of the V<sub>H</sub> segment of a rearranged V<sub>H</sub>DJ<sub>H</sub> may be replaced by all or part of another V<sub>H</sub> have been appearing since the 1980s ...
Brokaw JL +21 more
core +2 more sources
International Journal of Molecular Sciences, 2015 To understand the molecular evolution of mitochondrial genomes (mitogenomes) in the genus Odontobutis, the mitogenome of Odontobutis yaluensis was sequenced and compared with those of another four Odontobutis species.
Zhihong Ma +7 more
semanticscholar +1 more source
Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer
British Journal of Cancer, 2015 Background:Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies.Methods:We detected ALK protein ...
A. Amatu +21 more
semanticscholar +1 more source
Marfan syndrome with a complex chromosomal rearrangement including deletion of the
Molecular Cytogenetics, 2012 Background The majority of Marfan syndrome (MFS) cases is caused by mutations in the fibrillin-1 gene (FBN1), mapped to chromosome 15q21.1. Only few reports on deletions including the whole FBN1 gene, detected by molecular cytogenetic techniques, were ...
Colovati Mileny ES +8 more
doaj +1 more source
Chromosomal rearrangements as barriers to genetic homogenization between archaic and modern humans [PDF]
, 2015 Chromosomal rearrangements, which shuffle DNA throughout the genome, are an important source of divergence across taxa. Using a paired-end read approach with Illumina sequence data for archaic humans, I identify changes in genome structure that occurred recently in human evolution. Hundreds of rearrangements indicate genomic trafficking between the sex
arxiv +1 more source
Small Parsimony for Natural Genomes in the DCJ-Indel Model [PDF]
arXiv, 2021 Reconstructing ancestral gene orders is an important step towards understanding genome evolution. The Small Parsimony Problem (SPP) has been extensively studied in this regard. The problem aims at finding the gene orders at internal nodes of a given phylogenetic tree such that the overall genome rearrangement distance along the tree branches is ...
arxiv
Programmed Gene Rearrangements Altering Gene Expression
Science, 1987 Programmed gene rearrangements are used in nature to alter gene copy number (gene amplification and deletion), to create diversity by reassorting gene segments (as in the formation of mammalian immunoglobulin genes), or to control the expression of a set of genes that code for the same function (such as surface antigens).
Borst, P, Greaves, D
openaire +4 more sources