Results 171 to 180 of about 3,132,999 (350)

Epigenetic regulation of key gene of PCK1 by enhancer and super-enhancer in the pathogenesis of fatty liver hemorrhagic syndrome [PDF]

Yi Wang, Shuwen Chen, Min Xue, Jinhu Ma, Xinrui Yi, Xinyu Li, Xuejin Lu, Meizi Zhu, Jin Peng, Yunshu Tang, Yaling Zhu   +10 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Thermodynamic control of gene regulation. [PDF]

QRB Discov
Wells JW, Chalikian TV.
europepmc   +1 more source

Author response: Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

, 2018
Li Zhou, Mandy Yu Theng Lim, Prameet Kaur, Abil Saj, Diane Bortolamiol-Bécet, Vikneswaran Gopal, Nicholas S. Tolwinski, Greg Tucker‐Kellogg, Katsutomo Okamura   +8 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A CRISPRi Gene Regulation System for Bifidobacteria. [PDF]

Microb Biotechnol
Friess L, van Sinderen D, Lee C.
europepmc   +1 more source

Table S1. 12 genes responsible for temperature sensitivity were determined. from Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast

, 2018
Kenichi Sajiki, Yuria Tahara, Alejandro Villar‐Briones, Tomáš Pluskal, Takayuki Teruya, Ayaka Mori, Mitsuko Hatanaka, Masahiro Ebe, Takahiro Nakamura, Keita Aoki, Yukinobu Nakaseko, Mitsuhiro Yanagida   +11 more
openalex   +1 more source

Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings. [PDF]

, 1992
William Kubasek, A. Winkel, Ann McKillop, H. M. Goodman, Winslow R. Briggs, Frederick M. Ausubel   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Advances in miRNA research: Unraveling the complexities of gene regulation. [PDF]

Animal Model Exp Med
Zheng J, Zhang G, Ren L.
europepmc   +1 more source