Results 271 to 280 of about 2,989,814 (357)

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

A Modular Genetic Toolbox for Precise Gene Regulation and Multi-Color Imaging in Streptococci

Mignolet J, Staub J, van der Meer JR, Veening J, Libante V.   +4 more
europepmc   +1 more source

Zelda is dispensable for <i>Drosophila melanogaster</i> histone gene regulation. [PDF]

Mol Biol Cell
O'Haren T, Aoki T, Rieder LE.
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation. [PDF]

Mol Cancer
Li J, Xu L, Wang J, Wang X, Lin Y, Zou AY, Ren F, Wang Y, Li J, Chang Z.   +9 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Proximity-activated guide RNA of CRISPR-Cas12a for programmable diagnostic detection and gene regulation. [PDF]

Nucleic Acids Res
Hu Z, Ling S, Duan J, Yu Z, Che Y, Wang S, Zhang S, Zhang X, Li Z.   +8 more
europepmc   +1 more source

Molecular basis for modulated regulation of gene expression in the arginine regulon ofEscherichia coliK-12

, 1983
Raymond Cunin, Thomas Eckhardt, Jacques Piette, Anne Boyen, André Pierard, Nicolas Glansdorff   +5 more
openalex   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

A unified-field theory of genome organization and gene regulation. [PDF]

iScience
Negro G, Semeraro M, Cook PR, Marenduzzo D.   +3 more
europepmc   +1 more source