Results 61 to 70 of about 3,082,129 (201)
miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]
, 2019 open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J. +8 more
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A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj +1 more source
Gene autoregulation via intronic microRNAs and its functions [PDF]
, 2012 Background: MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases.
Baroudi, Mariama El +4 more
core +2 more sources
Administration of Insurance Rate Regulatory Laws [PDF]
, 1950 microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was
Ernberg, Ingemar +5 more
core +3 more sources
Dualistic role of ZEB1 and ZEB2 in tumor progression
Biology DirectIt is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev +6 more
doaj +1 more source
A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
Nature Communications, 2020 SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi +8 more
doaj +1 more source
Spatial clustering and common regulatory elements correlate with coordinated gene expression [PDF]
, 2019 Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can generate ...
Bai, Fan +6 more
core +3 more sources
Molecular Oncology, 2023 The biological functions of short open reading frame (sORF)‐encoded micropeptides remain largely unknown. Here, we report that LINC00998, a previously annotated lncRNA, was upregulated in multiple cancer types and the sORF on LINC00998 encoded a ...
Jin‐E Yang +8 more
doaj +1 more source
Cell Reports, 2016 Epithelial-to-mesenchymal transition (EMT) confers several traits to cancer cells that are required for malignant progression. Here, we report that miR-27b-3p-mediated silencing of the single-strand RNA binding protein KHSRP is required for transforming ...
Margherita Puppo +8 more
doaj +1 more source
miRNA/phasiRNA mediated regulation of plant defense response against P. syringae [PDF]
, 2018 Gene silencing is a mechanism of regulation of gene expression where the small RNAs (sRNAs) are key components for giving specificity to the system. In plants, two main types of noncoding small RNA molecules have been found: microRNAs (miRNAs) and small ...
Del Espino Pérez, Ángel +7 more
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