Results 261 to 270 of about 474,387 (314)

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Inferring cell-type-specific gene regulatory network from cellular transcriptomics data with GeneLink. [PDF]

Brief Bioinform
Zhang W, Shao B, Li W, Guo W, Lyu J, Chen G, Wang C, Liu ZP.   +7 more
europepmc   +1 more source

Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature

Advanced Healthcare Materials, EarlyView.
Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest, Katherine J. Young, Isabella K. Holtz, Mark Mc Veigh, James D. West, Leon M. Bellan   +5 more
wiley   +1 more source

Correction to: Critical assessment of the ability of Boolean threshold models to describe gene regulatory network dynamics. [PDF]

PNAS Nexus
europepmc   +1 more source

Inferring Gene Regulatory Network Architecture Underlying Complex Traits: An Integrative Analysis of Mutant Lifespan and Gene Expression Profiles Identifies Master Regulators and Key Functional Modules for Yeast Aging. [PDF]

Aging Cell
Ma M, Long J, Chen Y, Shao Y, Zhu M, Zheng J, Yang L, Xiao Y, Kaeberlein M, Kennedy BK, Zheng Y, Li H, Yang J.   +12 more
europepmc   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

BiGSM: Bayesian inference of gene regulatory network via sparse modelling. [PDF]

Bioinformatics
Qin H, Garbulowski M, Sonnhammer ELL, Chatterjee S.   +3 more
europepmc   +1 more source

Critical assessment of the ability of Boolean threshold models to describe gene regulatory network dynamics. [PDF]

PNAS Nexus
Kadelka C, Hari K.
europepmc   +1 more source

Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback. [PDF]

NPJ Syst Biol Appl
Castillo-Jiménez A, Garay-Arroyo A, Sánchez MP, Martínez-García JC, Álvarez-Buylla ER.   +4 more
europepmc   +1 more source

Gene regulatory network prediction using machine learning, deep learning, and hybrid approaches. [PDF]

For Res (Fayettev)
Mummadi ST, Islam MK, Busov V, Wei H.
europepmc   +1 more source