Results 1 to 10 of about 499,018 (284)
Discovering study-specific gene regulatory networks. [PDF]
PLoS ONE, 2014 Microarrays are commonly used in biology because of their ability to simultaneously measure thousands of genes under different conditions. Due to their structure, typically containing a high amount of variables but far fewer samples, scalable network ...
Valeria Bo +5 more
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Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
doaj +4 more sources
Gene regulatory networks elucidating huanglongbing disease mechanisms. [PDF]
PLoS ONE, 2013 Next-generation sequencing was exploited to gain deeper insight into the response to infection by Candidatus liberibacter asiaticus (CaLas), especially the immune disregulation and metabolic dysfunction caused by source-sink disruption.
Federico Martinelli +8 more
doaj +7 more sources
Quantum gene regulatory networks
npj Quantum Information, 2023 In this work, we present a quantum circuit model for inferring gene regulatory networks (GRNs) from single-cell transcriptomic data. The model employs qubit entanglement to simulate interactions between genes, resulting in competitive performance and ...
Cristhian Roman-Vicharra, James J. Cai
doaj +3 more sources
Glucocorticoid receptor-dependent gene regulatory networks. [PDF]
PLoS Genetics, 2005 While the molecular mechanisms of glucocorticoid regulation of transcription have been studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain unknown.
Phillip Phuc Le +6 more
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The role of master regulators in gene regulatory networks [PDF]
Papers in Physics, 2015 Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key ...
Enrique Hernández Lemus +3 more
doaj +1 more source
Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model.
PLoS Genetics, 2023 The gene regulatory structure of cells involves not only the regulatory relationship between two genes, but also the cooperative associations of multiple genes.
Jiacheng Wang, Yaojia Chen, Quan Zou
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The Inferred Cardiogenic Gene Regulatory Network in the Mammalian Heart [PDF]
, 2013 Cardiac development is a complex, multiscale process encompassing cell fate adoption, differentiation and morphogenesis. To elucidate pathways underlying this process, a recently developed algorithm to reverse engineer gene regulatory networks was ...
Bazil, Jason +6 more
core +8 more sources
Structure learning for gene regulatory networks.
PLoS Computational Biology, 2023 Inference of biological network structures is often performed on high-dimensional data, yet is hindered by the limited sample size of high throughput "omics" data typically available. To overcome this challenge, often referred to as the "small n, large p
Anthony Federico +3 more
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Chaotic motifs in gene regulatory networks. [PDF]
PLoS ONE, 2012 Chaos should occur often in gene regulatory networks (GRNs) which have been widely described by nonlinear coupled ordinary differential equations, if their dimensions are no less than 3. It is therefore puzzling that chaos has never been reported in GRNs
Zhaoyang Zhang +5 more
doaj +1 more source