Results 11 to 20 of about 261,824 (309)
Fan-out in gene regulatory networks [PDF]
Journal of Biological Engineering, 2010 Background In synthetic biology, gene regulatory circuits are often constructed by combining smaller circuit components. Connections between components are achieved by transcription factors acting on promoters. If the individual components behave as true
Sauro Herbert M, Kim Kyung H
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Gene regulatory networks [PDF]
Proceedings of the National Academy of Sciences, 2005 The Special Feature on gene regulatory networks in this issue of PNAS highlights an emerging field in the biosciences: gene regulatory networks that control animal development. The complex control systems underlying development have probably been evolving for more than a billion years.
Eric, Davidson, Michael, Levin
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Gene-centered regulatory networks [PDF]
Briefings in Functional Genomics, 2009 Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators.
Arda, H. Efsun, Walhout, Albertha J M
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Gradient descent optimization in gene regulatory pathways. [PDF]
PLoS ONE, 2010 BACKGROUND: Gene Regulatory Networks (GRNs) have become a major focus of interest in recent years. Elucidating the architecture and dynamics of large scale gene regulatory networks is an important goal in systems biology.
Mouli Das +2 more
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Logic of gene regulatory networks [PDF]
Current Opinion in Biotechnology, 2007 Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward.
Materna, Stefan C., Davidson, Eric H.
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TFAP2A orchestrates gene regulatory networks and tubular architecture in kidney outer medullary collecting ducts. [PDF]
JCI InsightLeiz J +5 more
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Synchrony in Gene Regulatory Networks
Physica D: Nonlinear phenomena, 2021 We consider two mathematical dynamical models of gene regulatory networks (GRNs) and obtain results on robust synchronization on these dynamical models based on the existing theoretical results in the coupled cell network formalism. We also explore the concepts of quotient networks and network lifting in the context of GRNs which are related to the ...
Aguiar, Manuela A. D. +2 more
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Supervised Learning of Gene Regulatory Networks [PDF]
Current Protocols in Plant Biology, 2020 AbstractIdentifying the entirety of gene regulatory interactions in a biological system offers the possibility to determine the key molecular factors that affect important traits on the level of cells, tissues, and whole organisms. Despite the development of experimental approaches and technologies for identification of direct binding of transcription ...
Razaghi-Moghadam, Zahra +1 more
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Communications Biology, 2023 Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks with causal relationships.
Masato Ishikawa +12 more
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Building developmental gene regulatory networks [PDF]
Birth Defects Research Part C: Embryo Today: Reviews, 2009 AbstractAnimal development is an elaborate process programmed by genomic regulatory instructions. Regulatory genes encode transcription factors and signal molecules, and their expression is under the control of cis‐regulatory modules that define the logic of transcriptional responses to the inputs of other regulatory genes.
Li, Enhu, Davidson, Eric H.
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