Results 31 to 40 of about 261,824 (309)

Survey of Research on Non-homogeneous Gene Regulatory Network Models [PDF]

Jisuanji kexue yu tansuo, 2023
In the field of bioinformatics, the construction of gene regulatory networks is crucial. In recent years, non-homogeneous dynamic Bayesian networks have become a common modeling tool for learning gene regulatory networks from gene expression time-series ...
ZHANG Qianqian, HU Chunling, ZHANG Jiayao, LI Dawei, SHAO Mingyi
doaj   +1 more source

Artificial Gene Regulatory Networks—A Review [PDF]

Artificial Life, 2019
In nature, gene regulatory networks are a key mediator between the information stored in the DNA of living organisms (their genotype) and the structural and behavioral expression this finds in their bodies, surviving in the world (their phenotype). They integrate environmental signals, steer development, buffer stochasticity, and allow evolution to ...
Cussat-Blanc, Sylvain, Harrington, Kyle, Banzhaf, Wolfgang   +2 more
openaire   +4 more sources

Dynamical Criticality in Gene Regulatory Networks

Complexity, 2018
A well-known hypothesis, with far-reaching implications, is that biological evolution should preferentially lead to states that are dynamically critical.
Marco Villani, Luca La Rocca, Stuart Alan Kauffman, Roberto Serra   +3 more
doaj   +1 more source

Effects of Time Point Measurement on the Reconstruction of Gene Regulatory Networks

Molecules, 2010
With the availability of high-throughput gene expression data in the post-genomic era, reconstruction of gene regulatory networks has become a hot topic.
Bairong Shen, Yuanyuan Zhang, Jiajia Chen, Yang Yang, Huangqiong Zhu, Wenying Yan   +5 more
doaj   +1 more source

Gene regulatory networks elucidating huanglongbing disease mechanisms. [PDF]

PLoS ONE, 2013
Next-generation sequencing was exploited to gain deeper insight into the response to infection by Candidatus liberibacter asiaticus (CaLas), especially the immune disregulation and metabolic dysfunction caused by source-sink disruption.
Federico Martinelli, Russell L Reagan, Sandra L Uratsu, My L Phu, Ute Albrecht, Weixiang Zhao, Cristina E Davis, Kim D Bowman, Abhaya M Dandekar   +8 more
doaj   +1 more source

GeRNet: a gene regulatory network tool [PDF]

Biosystems, 2017
Gene regulatory networks (GRNs) are crucial in every process of life since they govern the majority of the molecular processes. Therefore, the task of assembling these networks is highly important. In particular, the so called model-free approaches have an advantage modeling the complexities of dynamic molecular networks, since most of the gene ...
Dussaut, Julieta Sol, Gallo, Cristian Andrés, Cravero, Fiorella, Martínez, María Jimena, Carballido, Jessica Andrea, Ponzoni, Ignacio   +5 more
openaire   +3 more sources

Assessing regulatory information in developmental gene regulatory networks [PDF]

Proceedings of the National Academy of Sciences, 2017
Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far beyond the control of individual genes.
Peter, Isabelle S., Davidson, Eric H.
openaire   +3 more sources

Dynamical methods for target control of biological networks

Royal Society Open Science, 2023
Estimating the influence that individual nodes have on one another in a Boolean network is essential to predict and control the system’s dynamical behaviour, for example, detecting key therapeutic targets to control pathways in models of biological ...
Thomas Parmer, Filippo Radicchi
doaj   +1 more source

Regulation and dysregulation of microRNA - transcription factor axes in differentiation and neuroblastoma

Cellular and Molecular Life Sciences
Development is characterized by dynamic changes in gene expression as cells traverse genetic pathways and make lineage-specific commitments. Transcription factors, which drive gene expression, and microRNAs, the largest class of post-transcriptional ...
Fakhira H. Nazki, Cameron P. Bracken
doaj   +1 more source

Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities

BMC Bioinformatics, 2011
Background Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes.
Dickerson Julie A, Jarboe Laura R, Fu Yao   +2 more
doaj   +1 more source