Results 241 to 250 of about 172,174 (293)

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Gene therapy for dopamine replacement

, 2010
Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy.
Björklund T, Cederfjäll EA, Kirik D.
core   +4 more sources

Gene Replacement Therapy for Hereditary Emphysema?

JAMA: The Journal of the American Medical Association, 1989
FROM 20 000 to 40 000 persons in the United States have α 1 -antitrypsin deficiency, an autosomal recessive disorder that usually leads to emphysema early in life. Recently, therapy has become available that can help prevent the progression of this debilitating, eventually fatal, chronic lung disease.
Skolnick, Andrew
openaire   +2 more sources

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Viral Vectors in Gene Replacement Therapy

Biochemistry (Moscow), 2023
Throughout the years, several hundred million people with rare genetic disorders have been receiving only symptom management therapy. However, research and development efforts worldwide have led to the development of long-lasting, highly efficient, and safe gene therapy for a wide range of hereditary diseases.
Ekaterina, Minskaia, Alima, Galieva, Alexander D, Egorov, Roman, Ivanov, Alexander, Karabelsky   +4 more
openaire   +2 more sources

Gene Replacement Therapy Enters Second Year

JAMA: The Journal of the American Medical Association, 1991
ABSTRACT AT THE START of the second year after initial clinical use of gene replacement therapy, the patient is "doing exceptionally well," says R. Michael Blaese, MD, National Cancer Institute who, with W. French Anderson, MD, National Heart, Lung, and Blood Institute, is one of the principal National Institutes of Health (NIH) clinicians involved in ...
Marwick, Charles
openaire   +2 more sources

Adenoviral Vectors for Gene Replacement Therapy

Viral Immunology, 2004
Adenovirus-based vectors are promising vehicles for gene replacement therapy due to their ability to efficiently transduce a wide variety of proliferating and non-proliferating cells. Over the past decade, different versions of adenoviral vectors (Ads) have been developed.
Huibi, Cao, David R, Koehler, Jim, Hu
openaire   +2 more sources

Prospects for retinal gene replacement therapy

Trends in Genetics, 2009
Inherited retinal degeneration, which includes conditions such as retinitis pigmentosa and Leber congenital amaurosis (LCA), affects approximately 1/3000 of the population in the Western world. It is characterized by loss of vision and results from mutations in any one of >100 different genes.
Alexander J, Smith, James W, Bainbridge, Robin R, Ali   +2 more
openaire   +2 more sources