Results 261 to 270 of about 172,174 (293)
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Replacement and Suicide Gene Therapy for Targeted Treatment of Lung Cancer
Clinical Lung Cancer, 2005Lung cancer is the leading cause of cancer-related death in the developed world; consequently, novel therapeutic strategies are in high demand. A major problem with the present treatment modalities is the lack of tumor specificity giving rise to dose-limiting toxicity and side effects. Gene therapy constitutes an experimental approach gaining increased
Thomas T, Poulsen +2 more
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Gene therapy: Transgenic stem cells replace skin.
Nature, 2017SCOPUS: sh ...
Aragona, Mariaceleste, Blanpain, Cédric
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Gene Replacement Therapy for Duchenne Muscular Dystrophy
2019Duchenne muscular dystrophy (DMD) is a fatal, X-linked disease caused by mutations in the massive dystrophin gene that lead to extremely low or non-detectable levels of dystrophin. Conversely, Becker muscular dystrophy (BMD) is a highly variable and significantly less severe disease that results from truncated or poorly expressed dystrophin variants ...
Katrin Hollinger +2 more
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[Gene Replacement Therapy for Inherited Retinal Dystrophies].
Klinische Monatsblatter fur Augenheilkunde, 2017Characteristics of inherited retinal dystrophies include deficiencies in light perception and nervous conduction within the retina, leading to reduced vision or even blindness. In this context, the loss of function of photoreceptor-specific genes causes a variety of clinically and aetiologically distinct syndromes - each of them belonging to the group ...
R, Mühlfriedel +3 more
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[Gene replacement therapy in achromatopsia type 2].
Klinische Monatsblatter fur Augenheilkunde, 2014Achromatopsia is an autosomal recessive inherited retinal disease caused by a complete loss of cone photoreceptor function. About 80 % of achromatopsia patients show mutations in the alpha or beta subunit (A3 and B3) of the cGMP controlled cation channel CNG (cyclic nucleotide-gated channel) of cone photoreceptors.
R, Mühlfriedel +2 more
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Gene replacement strategies for the prevention and therapy of cancer
European Journal of Cancer, 1994J A, Roth +4 more
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Challenges of immune responses in gene replacement therapy.
IDrugs : the investigational drugs journal, 2005Permanent gene replacement therapy using viral carriers such as adenovirus or adenovirus-associated virus vectors has failed thus far in human patients, in part due to immune responses to antigens of the viral carrier, a problem that has remained underappreciated and thus largely unaddressed.
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