Results 31 to 40 of about 1,213,334 (312)

RFCell: A Gene Selection Approach for scRNA-seq Clustering Based on Permutation and Random Forest

Frontiers in Genetics, 2021
In recent years, the application of single cell RNA-seq (scRNA-seq) has become more and more popular in fields such as biology and medical research. Analyzing scRNA-seq data can discover complex cell populations and infer single-cell trajectories in cell
Yuan Zhao, Zhao-Yu Fang, Cui-Xiang Lin, Chao Deng, Yun-Pei Xu, Hong-Dong Li   +5 more
doaj   +1 more source

Selection in the evolution of gene duplications [PDF]

Genome Biology, 2002
Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function.In search of systematic
Fyodor A, Kondrashov, Igor B, Rogozin, Yuri I, Wolf, Eugene V, Koonin   +3 more
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CRIA: An Interactive Gene Selection Algorithm for Cancers Prediction Based on Copy Number Variations

Frontiers in Plant Science, 2022
Genomic copy number variations (CNVs) are among the most important structural variations of genes found to be related to the risk of individual cancer and therefore they can be utilized to provide a clue to the research on the formation and progression ...
Qiang Wu, Dongxi Li
doaj   +1 more source

Potential benefit from using an identified major gene in BLUP evaluation with truncation and optimal selection [PDF]

, 1999
This study investigates the benefit of including information on an identified major gene in the estimation of breeding values in BLUP selection programmes. Selection for a quantitative trait is controlled by polygenes and a major locus with known effect.
Ricardo Pong-Wong, Grundy, B, Woolliams, JA, Villanueva, B., Pong-Wong, R.; id_orcid, Beatriz Villanueva, Villanueva, B, Pong-Wong, R, John A. Woolliams, Grundy, B., Woolliams, John, Brian Grundy   +11 more
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SELECTION OF AN UNFAVOURABLE GENE-COMPLEX [PDF]

Evolution, 1949
It has been the general basis of the theory of natural selection that genes or gene-combinations improving the "fitness" of a species will tend to increase in frequency within the species, while those which are harmful will tend to decrease, as a result of selection.
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Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo [PDF]

, 2004
In gene therapy, a clinically relevant therapeutic effect requires long-term expression of the desired gene at a level sufficient to correct or at least alleviate the underlying gene defect.
Pfützner, Wolfgang, Vogel, Jonathan C.
core   +1 more source

A theoretical analysis of gene selection

Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004., 2004
A great deal of recent research has focused on the challenging task of selecting differentially expressed genes from microarray data ('gene selection'). Numerous gene selection algorithms have been proposed in the literature, but it is often unclear exactly how these algorithms respond to conditions like small sample-sizes or differing variances ...
Mukherjee, S, Roberts, S
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Response to mass selection when an identified major gene is segregating [PDF]

, 1998
A deterministic model to predict response with mass selection when a major locus is segregating is presented. The model uses a selection index framework in which the weight of the different components included in the index are adjusted to describe the ...
Ricardo Pong-Wong, Pong-Wong, R.; id_orcid, John A. Woolliams, Woolliams, John, John A Woolliams   +4 more
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Balancing Selection at the Tomato RCR3 Guardee Gene Family Maintains Variation in Strength of Pathogen Defense [PDF]

, 2012
Coevolution between hosts and pathogens is thought to occur between interacting molecules of both species. This results in the maintenance of genetic diversity at pathogen antigens (or so-called effectors) and host resistance genes such as the major ...
Anja C. Hörger, Rose, Laura E., Renier A. L. Van Der, Renier A. L. van der Hoorn (150148), Van Der Hoorn, RAL, van der Hoorn, RA, Hoerger, A., Rose, LE, Van der Hoorn, R., Muhammad Ilyas, Laura E Rose, Ilyas, M, Laura E. Rose (150153), Hörger, Anja C., Laura E. Rose, Hoerger, AC, Rose, L., Aurélien Tellier, Van Der Hoorn, Renier, Stephan, Wolfgang, Hörger, AC, Tellier, A, Tellier, A., Muhammad Ilyas (150134), Anja C Hörger, van der Hoorn, Renier A. L., Anja C. Hörger (150127), Tellier, Aurélien, Stephan, W., Wolfgang Stephan (14960), Aurélien Tellier (150142), Renier A L van der Hoorn, Wolfgang Stephan, Stephan, W, Ilyas, M., Ilyas, Muhammad   +35 more
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Selecting Genes by Test Statistics [PDF]

BioMed Research International, 2005
Gene selection is an important issue in analyzing multiclass microarray data. Among many proposed selection methods, the traditional ANOVA F test statistic has been employed to identify informative genes for both class prediction (classification) and discovery problems. However, the F test statistic assumes an equal variance. This assumption may not be
Chen, Dechang, Liu, Zhenqiu, Ma, Xiaobin, Hua, Dong   +3 more
openaire   +2 more sources