Bistability in feedback circuits as a byproduct of evolution of evolvability [PDF]
, 2006 Noisy bistable dynamics in gene regulation can underlie stochastic switching and is demonstrated to be beneficial under fluctuating environments. It is not known, however, if fluctuating selection alone can result in bistable dynamics. Using a stochastic
Ward, R +4 more
core +2 more sources
Gene Selection in Cancer Classification Using Sparse Logistic Regression with L1/2 Regularization
Applied Sciences, 2018 In recent years, gene selection for cancer classification based on the expression of a small number of gene biomarkers has been the subject of much research in genetics and molecular biology.
Shengbing Wu +3 more
doaj +1 more source
Gene Correlation Guided Gene Selection for Microarray Data Classification [PDF]
BioMed Research International, 2021 The microarray cancer data obtained by DNA microarray technology play an important role for cancer prevention, diagnosis, and treatment. However, predicting the different types of tumors is a challenging task since the sample size in microarray data is often small but the dimensionality is very high.
Dong Yang, Xuchang Zhu
openaire +2 more sources
Lethal Gene Drive Selects Inbreeding [PDF]
, 2016 AbstractThe use of ‘selfish’ gene drive systems to suppress or even extinguish populations has been proposed on theoretical grounds for almost half a century. Creating these genes has recently become possible with CRISPR technology. One seemingly feasible approach, originally proposed by Burt, is to create a homing endonuclease gene (HEG) that inserts ...
openaire +2 more sources
Genetic programming for mining DNA chip data from cancer patients [PDF]
, 2004 In machine learning terms DNA (gene) chip data is unusual in having thousands of attributes (the gene expression values) but few (
Buxton, BF, Langdon, WB
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Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae [PDF]
, 2019 The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacteria populations occupying different niches is not well understood.
Abbott +124 more
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The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa [PDF]
, 2007 Objective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele.
Barnes +21 more
core +2 more sources
A Novel Method to Efficiently Highlight Nonlinearly Expressed Genes
Frontiers in Genetics, 2020 For precision medicine, there is a need to identify genes that accurately distinguish the physiological state or response to a particular therapy, but this can be challenging.
Qifei Wang +7 more
doaj +1 more source
A conditional marker gene allowing both positive and negative selection in plants [PDF]
, 2004 Selectable markers enable transgenic plants or cells to be identified after transformation. They can be divided into positive and negative markers conferring a selective advantage or disadvantage, respectively.
Erikson, Oskar +2 more
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Evaluation of gene selection metrics for tumor cell classification
Genetics and Molecular Biology, 2004 Gene expression profiles contain the expression level of thousands of genes. Depending on the issue under investigation, this large amount of data makes analysis impractical. Thus, it is important to select subsets of relevant genes to work with.
Katti Faceli +2 more
doaj +1 more source