Results 61 to 70 of about 1,213,334 (312)

Optimization of gene expression by natural selection [PDF]

Proceedings of the National Academy of Sciences, 2009
It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied molecular phenotype, the extent to which stabilizing selection limits divergence in gene expression remains contentious ...
Bedford, Trevor, Hartl, Daniel
openaire   +4 more sources

GENE FLOW AND SELECTION IN A CLINE [PDF]

Genetics, 1973
ABSTRACT A model of the effect of gene flow and natural selection in a continuously distributed, infinite population is developed. Different patterns of spatial variation in selective pressures are considered, including a step change in the environment, a "pocket" in the environment and a periodically varying environment.
openaire   +2 more sources

Sensory trait variation in an echolocating bat suggests roles for both selection and plasticity [PDF]

, 2014
Background: Across heterogeneous environments selection and gene flow interact to influence the rate and extent of adaptive trait evolution. This complex relationship is further influenced by the rarely considered role of phenotypic plasticity in the ...
Lizelle J Odendaal, Bishop, Jacqueline M, Jacobs, David S, Jacqueline M Bishop, Odendaal, Lizelle J, David S Jacobs   +5 more
core   +1 more source

Gene Selection for Classifications Using Multiple PCA with Sparsity

Tsinghua Science and Technology, 2012
A gene selection algorithm was developed using Multiple Principal Component Analysis with Sparsity (MSPCA). The MSPCA algorithm is used to analyze normal and disease gene expression samples and to set these component loadings to zero if they are smaller ...
Yanwei Huang, Liqing Zhang
doaj   +1 more source

Diagnosis of the disease using an ant colony gene selection method based on information gain ratio using fuzzy rough sets [PDF]

Journal of Particle Science and Technology, 2017
With the advancement of metagenome data mining science has become focused on microarrays. Microarrays are datasets with a large number of genes that are usually irrelevant to the output class; hence, the process of gene selection or feature selection is ...
Mohammad Masoud Javidi, Sedighe Mansoury
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]

, 2015
The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Zimmer, F, Mank, JE, Wright, AE, Dean, R, Harrison, PW   +4 more
core  

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection [PDF]

, 2009
Background: There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5 delta 32) cells, setting ...
Trobridge, Grant D., Chiu Sum Ying, Brian C Beard, Robert A Wu, John J Rossi, Muñoz Nina M., Nina M Muñoz, John J. Rossi, Brian C. Beard, Dorothee von Laer, Laer, Dorothee von, Grant D Trobridge, Beard Brian C., Chiu, Sum Ying, Nina M. Muñoz, Kiem, Hans-Peter, Sum Ying Chiu, Trobridge Grant D., Wu, Robert A., Hans-Peter Kiem, Kiem Hans-Peter, Beard, Brian C., Wu Robert A., von Laer Dorothee, Rossi, John J., Rossi John J., Grant D. Trobridge, Robert A. Wu, Muñoz, Nina M.   +28 more
core   +1 more source

A Systematic Evaluation of Supervised Machine Learning Algorithms for Cell Phenotype Classification Using Single-Cell RNA Sequencing Data

Frontiers in Genetics, 2022
The new technology of single-cell RNA sequencing (scRNA-seq) can yield valuable insights into gene expression and give critical information about the cellular compositions of complex tissues.
Xiaowen Cao, Xiaowen Cao, Li Xing, Elham Majd, Hua He, Junhua Gu, Xuekui Zhang   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source