Results 81 to 90 of about 1,213,334 (312)
iRGvalid: A Robust in silico Method for Optimal Reference Gene Validation
Frontiers in Genetics, 2021 BackgroundAppropriate reference genes are critical to accurately quantifying relative gene expression in research and clinical applications. Numerous efforts have been made to select the most stable reference gene(s), but a consensus has yet to be ...
Zhongxu Zhu, Keqin Gregg, Wenli Zhou
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Independent stratum formation on the avian sex chromosomes reveals inter-chromosomal gene conversion and predominance of purifying selection on the w chromosome [PDF]
, 2014 We used a comparative approach spanning three species and 90 million years to study the evolutionary history of the avian sex chromosomes. Using whole transcriptomes, we assembled the largest cross-species dataset of W-linked coding content to date.
Wright, Alison E +9 more
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Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
eLife, 2021 A major goal of cancer genomics is to identify all genes that play critical roles in carcinogenesis. Most approaches focused on genes positively selected for mutations that drive carcinogenesis and neglected the role of negative selection.
László Bányai +4 more
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A gene-level test for directional selection on gene expression
GENETICS, 2022 Abstract Most variants identified in human genome-wide association studies and scans for selection are noncoding. Interpretation of their effects and the way in which they contribute to phenotypic variation and adaptation in human populations is therefore limited by our understanding of gene regulation and the difficulty of ...
Laura L. Colbran +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On the Unit of Selection in Sexual Populations [PDF]
, 2005 Evolution by natural selection is a process of variation and selection acting on replicating units. These units are often assumed to be individuals, but in a sexual population, the largest reliably-replicated unit on which selection can act is a small ...
Richard A. Watson, Watson, Richard A.
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Biomarker Gene Signature Discovery Integrating Network Knowledge
Biology, 2012 Discovery of prognostic and diagnostic biomarker gene signatures for diseases, such as cancer, is seen as a major step towards a better personalized medicine.
Holger Fröhlich, Yupeng Cun
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Sequence diversity and potential recombination events in the coat protein gene of Apple stem pitting virus. [PDF]
, 2011 The variability of the Apple stem pitting virus (ASPV) coat protein (CP) gene was investigated. The CP gene of ten virus isolates from apple and pear trees was sequenced.
Paweł Siedlecki +9 more
core +1 more source