Results 81 to 90 of about 2,115,238 (295)

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy. [PDF]

, 2017
Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme ...
Castanotto, Daniela, Li, Haitang, Pang, Ka Ming, Rossi, John J, Scherer, Lisa   +4 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

An optimization-based framework for gene expression-based diagnostic classification of Wilms tumor

Machine Learning: Science and Technology
In this study, eSRA is a novel optimization algorithm proposed to enhance machine learning model efficiency in large-scale problems with numerous dimensions and intricate patterns.
Mohammed Qaraad, Tianshun Zhang, David Guinovart   +2 more
doaj   +1 more source

Machine Learning Based Computational Gene Selection Models: A Survey, Performance Evaluation, Open Issues, and Future Research Directions

Frontiers in Genetics, 2020
Gene Expression is the process of determining the physical characteristics of living beings by generating the necessary proteins. Gene Expression takes place in two steps, translation and transcription.
Nivedhitha Mahendran, P. M. Durai Raj Vincent, Kathiravan Srinivasan, Chuan-Yu Chang   +3 more
doaj   +1 more source

Gene-Wide Identification of Episodic Selection [PDF]

Molecular Biology and Evolution, 2015
We present BUSTED, a new approach to identifying gene-wide evidence of episodic positive selection, where the non-synonymous substitution rate is transiently greater than the synonymous rate. BUSTED can be used either on an entire phylogeny (without requiring an a priori hypothesis regarding which branches are under positive selection) or on a pre ...
Murrell, Ben, Weaver, Steven, Smith, Martin D., Wertheim, Joel O., Murrell, Sasha, Aylward, Anthony, Eren, Kemal, Pollner, Tristan, Martin, Darren P., Smith, Davey M., Scheffler, Konrad, Kosakovsky Pond, Sergei L.   +11 more
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Reference gene selection and RNA preservation protocol in the cat flea, Ctenocephalides felis, for gene expression studies [PDF]

, 2016
This work was supported by a Knowledge Transfer Network BBSRC Industrial Case (#414 BB/L502467/1) studentship in association Zoetis Inc.Peer ...
Baird, John, Bowman, Alan S, Campbell, Ewan M, McIntosh, Catriona H, Woods, Debra J., Zinser, Erich   +5 more
core   +1 more source

New Bio-Marker Gene Discovery Algorithms for Cancer Gene Expression Profile

IEEE Access, 2019
Several hybrid gene selection algorithms for cancer classification that employ bio-inspired evolutionary wrapper algorithm have been proposed in the literature and show good classification accuracy.
Nada Almugren, Hala M. Alshamlan
doaj   +1 more source

Universal Nature of Drug Treatment Responses in Drug-Tissue-Wide Model-Animal Experiments Using Tensor Decomposition-Based Unsupervised Feature Extraction

Frontiers in Genetics, 2020
Gene expression profiles of tissues treated with drugs have recently been used to infer clinical outcomes. Although this method is often successful from the application point of view, gene expression altered by drugs is rarely analyzed in detail, because
Yh. Taguchi, Turki Turki
doaj   +1 more source

Human pigmentation genes under environmental selection [PDF]

Genome Biology, 2012
Genome-wide association studies and comparative genomics have established major loci and specific polymorphisms affecting human skin, hair and eye color. Environmental changes have had an impact on selected pigmentation genes as populations have expanded into different regions of the globe.
Sturm, Richard A., Duffy, David L.
openaire   +3 more sources