Results 91 to 100 of about 2,115,238 (295)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A novel gene expression test method of minimizing breast cancer risk in reduced cost and time by improving SVM-RFE gene selection method combined with LASSO

Journal of Integrative Bioinformatics, 2020
Breast cancer is the leading diseases of death in women. It induces by a genetic mutation in breast cancer cells. Genetic testing has become popular to detect the mutation in genes but test cost is relatively expensive for several patients in developing ...
Gupta Madhuri, Gupta Bharat
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integrated genomic and transcriptomic analysis of polydactyly in chickens

Frontiers in Veterinary Science
IntroductionPolydactyly—the presence of extra digits—is a heritable limb anomaly observed in several chicken breeds. The Puan Panjiang black-bone chicken uniquely exhibits both four- and five-toed phenotypes, yet the genetic and transcriptional bases of ...
Zhiying Huang, Xiaomeng Miao, Diyan Li, Jia Liu, Haolin Chen, Yuan Su, Yuan Su   +6 more
doaj   +1 more source

A Novel Deep Flexible Neural Forest Model for Classification of Cancer Subtypes Based on Gene Expression Data

IEEE Access, 2019
Classification of cancer subtypes is of paramount importance for diagnosis and prognosis of cancer. In recent years, deep learning methods have gained considerable popularity for cancer subtype classification, however, the structure of the neural network
Jing Xu, Peng Wu, Yuehui Chen, Qingfang Meng, Hussain Dawood, Muhammad Murtaza Khan   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Survey on Hybrid Feature Selection Methods in Microarray Gene Expression Data for Cancer Classification

IEEE Access, 2019
The emergence of DNA Microarray technology has enabled researchers to analyze the expression level of thousands of genes simultaneously. The Microarray data analysis is the process of finding the most informative genes as well as remove redundant and ...
Nada Almugren, Hala Alshamlan
doaj   +1 more source

Statistical modeling for selecting housekeeper genes [PDF]

Genome Biology, 2004
Statistical models are presented for selecting the best housekeepers to normalize quantitative data within a given tissue type and across different types of tissue samples.There is a need for statistical methods to identify genes that have minimal variation in expression across a variety of experimental conditions.
Aniko, Szabo, Charles M, Perou, Mehmet, Karaca, Laurent, Perreard, Robert, Palais, John F, Quackenbush, Philip S, Bernard   +6 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source