Results 1 to 10 of about 631,661 (355)

The Iterative Signature Algorithm for the analysis of large scale gene expression data [PDF]

, 2002
We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data.
A. Brazma, A. Schulze, C.M. Perou, D.D. Lee, E. Lander, G. Getz, G. Sherlock, J. Ihmels, J.E. Staunton, J.L. DeRisi, Jan Ihmels, L. Lazzeroni, M. Bittner, M. Bittner, M. Schena, M.B. Eisen, N.S. Holter, Naama Barkai, O. Alter, P. Tamayo, P.T. Spellman, R.B. Altman, S. Tavazoie, Sven Bergmann, T. Hastie, T.G. Kolda, U. Alon, U. Scherf, Y. Cheng   +28 more
core   +2 more sources

Computational prediction of diagnostic biomarker candidates and prognostic gene signature from DNA replication-related genes in breast cancer [PDF]

Discover Oncology
Background Given the role of DNA replication in tumorigenesis, identifying diagnostic and prognostic biomarkers of this process using machine learning approaches may reveal new therapeutic targets and improve prognostic assessment in breast cancer ...
Ceren Sucularli
doaj   +2 more sources

Construction and validation of a novel gene signature for predicting the prognosis of osteosarcoma

Scientific Reports, 2022
Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-throughput sequencing technology has shown potential abilities to illuminate the pathogenic genes in OS.
Jinpo Yang, Anran Zhang, Huan Luo, Chao Ma   +3 more
doaj   +1 more source

Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma [PDF]

PeerJ, 2020
Background Due to the complicated molecular and cellular heterogeneity in hepatocellular carcinoma (HCC), the morbidity and mortality still remains high level in the world.
Zhipeng Zhu, Lulu Li, Jiuhua Xu, Weipeng Ye, Borong Chen, Junjie Zeng, Zhengjie Huang   +6 more
doaj   +2 more sources

CoMI: consensus mutual information for tissue-specific gene signatures

BMC Bioinformatics, 2022
Background The gene signatures have been considered as a promising early diagnosis and prognostic analysis to identify disease subtypes and to determine subsequent treatments.
Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yi-Hsuan Chuang, Jung-Yu Lee, Jinn-Moon Yang   +5 more
doaj   +1 more source

Comprehensive Integration of Genome-Wide Association and Gene Expression Studies Reveals Novel Gene Signatures and Potential Therapeutic Targets for Helicobacter pylori-Induced Gastric Disease

Frontiers in Immunology, 2021
Helicobacter pylori is a gram-negative bacterium that colonizes the human gastric mucosa and can lead to gastric inflammation, ulcers, and stomach cancer. Due to the increase in H.
Mohamed Tarek Badr, Mohamed Tarek Badr, Mohamed Omar, Georg Häcker, Georg Häcker   +4 more
doaj   +1 more source

Association between a Prognostic Gene Signature and Functional Gene Sets

Bioinformatics and Biology Insights, 2008
Background The development of expression-based gene signatures for predicting prognosis or class membership is a popular and challenging task. Besides their stringent validation, signatures need a functional interpretation and must be placed in a ...
Manuela Hummel, Klaus H. Metzeler, Christian Buske, Stefan K. Bohlander, Ulrich Mansmann   +4 more
doaj   +2 more sources

Construction and Validation of an Oxaliplatin-Resistant Gene Signature in Colorectal Cancer Patients Who Underwent Chemotherapy

Pharmaceuticals, 2022
Aberrant expression of genes contributes to the chemoresistance of colorectal cancer (CRC) treatment. This study aimed to identify genes associated with the chemoresistance of oxaliplatin-based chemotherapy in CRC patients and to construct a signature ...
Yixin Yin, Siqi Li, Xinqiang Liang, Kezhi Li, Mingzhi Xie, Bangli Hu   +5 more
doaj   +1 more source

A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma [PDF]

PeerJ, 2021
Background Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk.
Zhengyuan Wu, Leilei Chen, Chaojie Jin, Jing Xu, Xingqun Zhang, Yi Yao   +5 more
doaj   +2 more sources

Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma

Frontiers in Genetics, 2020
BackgroundBladder carcinoma (BC) is one of the most prevalent and malignant tumors. Multiple gene signatures based on BC metabolism, especially regarding glycolysis, remain unclear. Thus, we developed a glycolysis-related gene signature to be used for BC
Zezhong Mou, Zezhong Mou, Chen Yang, Chen Yang, Chen Yang, Zheyu Zhang, Zheyu Zhang, Siqi Wu, Siqi Wu, Chenyang Xu, Chenyang Xu, Zhang Cheng, Zhang Cheng, Xiyu Dai, Xiyu Dai, Xinan Chen, Xinan Chen, Yuxi Ou, Yuxi Ou, Haowen Jiang, Haowen Jiang, Haowen Jiang   +21 more
doaj   +1 more source