Results 11 to 20 of about 631,661 (355)
SIGNATURE: A workbench for gene expression signature analysis [PDF]
BMC Bioinformatics, 2011 Background The biological phenotype of a cell, such as a characteristic visual image or behavior, reflects activities derived from the expression of collections of genes.
Chang Jeffrey T +5 more
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Detecting signatures of selection on gene expression [PDF]
Nature Ecology & Evolution, 2022 A substantial amount of phenotypic diversity results from changes in gene expression levels and patterns. Understanding how the transcriptome evolves is therefore a key priority in identifying mechanisms of adaptive change. However, in contrast to powerful models of sequence evolution, we lack a consensus model of gene expression evolution. Furthermore,
Peter D. Price +8 more
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Signature Genes as a Phylogenomic Tool [PDF]
Molecular Biology and Evolution, 2008 Gene content has been shown to contain a strong phylogenetic signal, yet its usage for phylogenetic questions is hampered by horizontal gene transfer and parallel gene loss and until now required completely sequenced genomes. Here, we introduce an approach that allows the phylogenetic signal in gene content to be applied to any set of sequences, using ...
Dutilh, B.E. +3 more
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Gene signature of the embryonic meniscus [PDF]
Journal of Orthopaedic Research, 2013 ABSTRACTThe meniscus is a fibrocartilagenous disc in the knee that protects the joint from damage. Meniscal injuries are common, however repair efforts are largely unsuccessful and are not able to prevent the degenerative changes that result in development of osteoarthritis.
Luciane P. Capelo +4 more
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Refining gene signatures: a Bayesian approach [PDF]
BMC Bioinformatics, 2009 In high density arrays, the identification of relevant genes for disease classification is complicated by not only the curse of dimensionality but also the highly correlated nature of the array data. In this paper, we are interested in the question of how many and which genes should be selected for a disease class prediction.
Amira Djebbari +2 more
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BMC Cancer, 2021 Background The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes ...
Weifeng Zheng +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: Cancer-associated fibroblasts (CAFs) are mainly involved in cancer progression and treatment failure. However, the specific signature of CAFs and their related clinicopathological parameters in renal cell carcinoma (RCC) remain unclear. Here,
Bitian Liu +4 more
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Frontiers in Genetics, 2020 Malignant pleural mesothelioma (MPM), predominantly caused by asbestos exposure, is a highly aggressive cancer with poor prognosis. The staging systems currently used in clinics is inadequate in evaluating the prognosis of MPM. In this study, a five-gene
Yiyang Bai +9 more
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Identification of autoimmune gene signatures in autism [PDF]
Translational Psychiatry, 2011 The role of the immune system in neuropsychiatric diseases, including autism spectrum disorder (ASD), has long been hypothesized. This hypothesis has mainly been supported by family cohort studies and the immunological abnormalities found in ASD patients, but had limited findings in genetic association testing.
Isaac S. Kohane +4 more
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An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. [PDF]
PLoS ONE, 2014 AIMS: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer.
Monica Mannelqvist +3 more
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