Results 21 to 30 of about 649,536 (308)
An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma
Frontiers in Molecular Biosciences, 2021 Objective: Immunity plays a vital role in the human papilloma virus (HPV) persistent infection, and closely associates with occurrence and development of cervical squamous cell carcinoma (CSCC).
Huixia Yang, Xiaoyan Han, Zengping Hao
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia +17 more
doaj +1 more source
NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. [PDF]
, 2019 The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene ...
Bodzin, Adam S. +9 more
core +3 more sources
BMC Medical Genomics, 2019 Background We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. Methods Two hundred forty-three patients with
Michelle Petri +6 more
doaj +1 more source
Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]
, 2019 Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina +8 more
core +1 more source
Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes [PDF]
, 2012 Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Ana B. Martínez-Cruz +16 more
core +12 more sources
SIGNATURE: A workbench for gene expression signature analysis
BMC Bioinformatics, 2011 Background The biological phenotype of a cell, such as a characteristic visual image or behavior, reflects activities derived from the expression of collections of genes.
Chang Jeffrey T +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 BackgroundGlioma is the most common primary malignant brain tumor with significant mortality and morbidity. Ferroptosis, a novel form of programmed cell death (PCD), is critically involved in tumorigenesis, progression and metastatic processes.MethodsWe ...
Zhuohui Chen +3 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundLung squamous cell carcinoma (LUSC) generally correlates with poor clinical prognoses due to the lack of available prognostic biomarkers. This study is designed to identify a potential biomarker significant for the prognosis and treatment of ...
Cailian Wang +4 more
doaj +1 more source
Signature of arylacetamide deacetylase expression is associated with prognosis and immune infiltration in ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2022 Objective The role of the protein-coding gene arylacetamide deacetylase (AADAC) in the prognostication of ovarian cancer remains uncertain. We aimed to identify and validate its prognostic value using integrated bioinformatics analyses.
Jianyang Feng, Hong He
doaj +1 more source