Results 201 to 210 of about 7,554,622 (397)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

A <i>Begomovirus solanumdelhiense</i> Vector for Virus-Induced Gene Silencing in Melon. [PDF]

Pathogens
Han Y, Liao Q, Gao P, Zhang L, Wan B, Xu L, Gao S, Song Z, Dai F, Zeng R.   +9 more
europepmc   +1 more source

Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus

, 2004
Xiaoxiang Hu
openalex   +2 more sources

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Journal of the American Chemical Society, 2014
Jayaprakash K Nair, J. Willoughby, A. Chan, K. Charissé, Md. Rowshon Alam, Qianfan Wang, M. Hoekstra, P. Kandasamy, A. Kel'in, S. Milstein, Nate Taneja, Jonathan O’Shea, Sarfraz Shaikh, Ligang Zhang, R. J. van der Sluis, M. Jung, Akin Akinc, R. Hutabarat, S. Kuchimanchi, K. Fitzgerald, Tracy S. Zimmermann, T. V. van Berkel, M. Maier, K. G. Rajeev, M. Manoharan   +24 more
semanticscholar   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes. [PDF]

Nat Commun
Antunes LB, Isebe T, Kutova O, Cestari I.   +3 more
europepmc   +1 more source

Development of a gene silencing DNA vector derived from a broad host range geminivirus [PDF]

, 2009
Edward M. Golenberg, D. Noah Sather, Leandria C. Hancock, Kenneth J. Buckley, Natalie Villafranco, David M. Bisaro   +5 more
openalex   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Chemically inducible antisense oligonucleotides for cell-specific gene silencing. [PDF]

RSC Chem Biol
Xun Z, Hai Y, Tang LJ, Jiang JH, Wu Z.
europepmc   +1 more source

Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap [PDF]

, 2005
Tsukasa Nabekura, Makoto Otsu, Toshiro Nagasawa, Hiromitsu Nakauchi, Masafumi Onodera   +4 more
openalex   +1 more source