Results 251 to 260 of about 355,065 (295)

Single-cell encoded gene silencing for high-throughput combinatorial siRNA screening. [PDF]

Nat Commun
Guo F, Ji X, Xiong C, Sun H, Liang Z, Yan-Do R, Gai B, Gao F, Huang L, Li Z, Kuang BY, Shi P.   +11 more
europepmc   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

A novel gene silencing strategy based on tobacco rattle virus in Hibiscus mutabilis. [PDF]

PeerJ
Sang S, Liu Y, Li X, Ma J, Liu X, Yang Y.   +5 more
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy. [PDF]

PeerJ
Küçükekmekci B, Budak Yıldıran FA.
europepmc   +1 more source

Host-induced gene silencing of the amino acid biosynthesis gene acetolactate synthase of Phytophthora infestans caused strong enhanced late blight resistance of potato in the field. [PDF]

Plant Biotechnol J
Temme N, Haehre T, Boyher C, Hoppe L, Davenport C, Stumo Z, Prenzler K, Maeser A, Pflugmacher M, Koch K, Stahl DJ.   +10 more
europepmc   +1 more source

Spray-induced gene silencing enables the characterization of gene function during pre-penetration stages in <i>Blumeria graminis</i> f. sp. <i>tritici</i>. [PDF]

Front Plant Sci
Zhang M, Zhou M, Jia Y, Li X, Wang A, Liu T, Zhou Y, Liu W, Fan J.   +8 more
europepmc   +1 more source

Cre-Lox miRNA-delivery technology optimized for inducible microRNA and gene-silencing studies in zebrafish. [PDF]

Nucleic Acids Res
Guo F, Tromp A, Wang H, Hall TE, Giacomotto J.   +4 more
europepmc   +1 more source

Virus-Induced Gene Silencing (VIGS) in Hydrangea macrophylla and Functional Analysis of HmF3'5'H. [PDF]

Plants (Basel)
Yang Q, Fan Y, Luo S, Liu C, Yuan S.
europepmc   +1 more source

In Vivo HOXB7 Gene Silencing and Cotreatment with Tamoxifen for Luminal A Breast Cancer Therapy. [PDF]

Pharmaceuticals (Basel)
Valle ABCDS, da Silva FFA, Carneiro MÂP, Espuche B, Tavares GD, Bernardes ES, Moya SE, Pittella F.   +7 more
europepmc   +1 more source