Results 241 to 250 of about 623,056 (302)

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Establishment and optimization of a tobacco rattle virus -based virus-induced gene Silencing in Atriplex canescens. [PDF]

Plant Methods
Feng S, Chen JD, Bao AK.
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

DsiRNA-mediated silencing of Ceratitis capitata transformer or transformer-2 leads to masculinization of XX embryos and systemic gene silencing in ovaries. [PDF]

Insect Sci
Volpe G, Mazzucchiello SM, De Falco D, Torrente D, Liguori S, Rosati N, Baccaro D, Mazzeo M, Bertolotto F, Sangle H, Giordano E, Carfora A, Lucibelli F, Varone M, Di Lillo P, Perdomo HD, Bonizzoni M, Aceto S, Salvemini M, Duman-Scheel M, Saccone G.   +20 more
europepmc   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

RNAi spray-induced gene silencing of <i>EPSPS</i> by topical application of dsRNA in the weed <i>Digitaria insularis</i>. [PDF]

Front Plant Sci
Cintra LA, Da Rosa J, De Assis R, Marin SRR, Adegas FS, Rech EL, Nepomuceno AL, Mertz-Henning LM.   +7 more
europepmc   +1 more source

Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys. [PDF]

Adv Biol (Weinh)
Amineni VPS, Petschenka G, Koch A.
europepmc   +1 more source

Regulatory role of vitamin D₃ on myogenesis and fibrogenesis under Vdr gene silencing and TGF-β1 stimulation in skeletal muscle cells. [PDF]

Sci Rep
Watcharanapapan W, Hirunsai M, Srikuea R.   +2 more
europepmc   +1 more source

Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia. [PDF]

Cancer Immunol Immunother
Ferreira D, Asín L, Idiago-López J, Grazú V, de la Fuente JM, Fratila RM, Baptista PV, Fernandes AR.   +7 more
europepmc   +1 more source