Results 271 to 280 of about 355,065 (295)
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Science, 2001
In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
Jan M. Kooter +2 more
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In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.
Jan M. Kooter +2 more
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Methods for Gene Silencing With RNAi
2007This chapter describes a technique for synthesizing and transfecting double stranded RNA (dsRNA) for RNA interference in Sf-21 cell culture. Transfection with dsRNA only requires 1 h and the cells are usually recovered within 12 h. Suggestions for designing dsRNA are included in the methods.
William E. Bentley, John C. March
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Application of gene silencing in plants
Current Opinion in Plant Biology, 2002Recent studies of gene silencing in plants have revealed two RNA-mediated epigenetic processes, RNA-directed RNA degradation and RNA-directed DNA methylation. These natural processes have provided new avenues for developing high-efficiency, high-throughput technology for gene suppression in plants.
Wang, Ming-Bo, Waterhouse, Peter M.
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2000
Preface. 1. Paramutation in maize V.L. Chandler, et al. 2. Genomic imprinting in plants - observations and evolutionary implications M. Alleman, J. Doctor. 3. Nucleolar Dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids G. Pikaard. 4. Epigenetic aspects of somaclonal variation in plants S.M. Kaeppler, et al. 5. Plant DNA
M. A. Matzke, A. J. M. Matzke
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Preface. 1. Paramutation in maize V.L. Chandler, et al. 2. Genomic imprinting in plants - observations and evolutionary implications M. Alleman, J. Doctor. 3. Nucleolar Dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids G. Pikaard. 4. Epigenetic aspects of somaclonal variation in plants S.M. Kaeppler, et al. 5. Plant DNA
M. A. Matzke, A. J. M. Matzke
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Chemical & Engineering News Archive, 2013
When new protein structures are reported, it’s often claimed they could lead to the design of therapeutic agents that interact with the proteins more effectively. A new study on short interfering RNAs (siRNAs) actually demonstrates such a result. Last year, two research groups determined crystal structures of the human version of Argonaute—a protein in
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When new protein structures are reported, it’s often claimed they could lead to the design of therapeutic agents that interact with the proteins more effectively. A new study on short interfering RNAs (siRNAs) actually demonstrates such a result. Last year, two research groups determined crystal structures of the human version of Argonaute—a protein in
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Posttranscriptional Gene Silencing
2009Regenerative medicine is an emerging field that has been extensively studied and includes modern approaches for gene targeting. Recent findings have highlighted the effectiveness of gene silencing in therapeutic settings [1–7]. The key therapeutic advantage of using RNA interference (RNAi) lies in an ability to downregulate the expression of an ...
Sabine Pankuweit +3 more
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Aging: gene silencing or gene activation?
Medical Hypotheses, 2005According to the author's theory of gene silencing, the key process in aging involves reduced expression of a number of genes. Silencing of genes has a complex mechanism, which involves methylation of DNA, histone modification and chromatin remodeling.
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The Silence of the Flowering Genes
Science's STKE, 2007Transcription of genes is controlled by specific factors at each promoter and by a general state of activation or silencing in the surrounding chromatin. In the course of studying chromatin silencing in the plant Arabidopsis , Bäurle et al . noticed a defect in flowering.
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2003
In the postgenomic era, large-scale functional genomic approaches are necessary for converting sequence information into functional information. A para-genetic approach, called virus-induced gene silencing (VIGS), offers a rapid means of gaining insight into gene function in plants.
Rajendra Marathe +4 more
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In the postgenomic era, large-scale functional genomic approaches are necessary for converting sequence information into functional information. A para-genetic approach, called virus-induced gene silencing (VIGS), offers a rapid means of gaining insight into gene function in plants.
Rajendra Marathe +4 more
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The silence of the ribosomal RNA genes
Cellular and Molecular Life Sciences, 2005Over the past decade emerging evidence has indicated that epigenetic factors control and regulate nuclear processes. The genes encoding ribosomal RNA (rRNA) represent an ideal model to study how epigenetics and chromatin can modulate gene expression.
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