Results 271 to 280 of about 7,554,622 (397)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer. [PDF]

ACS Appl Mater Interfaces
Rebolledo LP, Anil Kumar Jeeja P, Danai L, Binte Huq T, Afonin KA, Vivero-Escoto JL.   +5 more
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing. [PDF]

Mol Ther Nucleic Acids
Huang ZA, Li ZM, Wang J, Ji GS, Gao ZC, Chen AF, Tian ZK, Yu F, Song GS.   +8 more
europepmc   +1 more source

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

Science, 2012
Sergej Djuranovic, A. Nahvi, R. Green
semanticscholar   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Strategic Timing of Gene Silencing: Cellular Kinetics-Based Administration of siRNA for Optimized Photothermal Cancer Treatment. [PDF]

Adv Sci (Weinh)
Fang T, Li L, Tariq Muhseen Z, Lane LA, Cai H, Butch CJ, Wang Y.   +6 more
europepmc   +1 more source

Tricks in Plasmodium’s molecular repertoire – Escaping 3′UTR excision-based conditional silencing of the chloroquine resistance transporter gene

, 2012
Andrea Ecker, Rebecca E. Lewis, Eric H. Ekland, Bamini Jayabalasingham, David A. Fidock   +4 more
openalex   +2 more sources

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Truncated CMV2b^N43 enhances virus-induced gene silencing in pepper by retaining systemic but not local silencing suppression. [PDF]

Plant Methods
Zhou Y, Wang Y, Huang D, Li F.
europepmc   +1 more source