Results 41 to 50 of about 7,098,593 (382)

Gene silencing in tick cell lines using small interfering or long double-stranded RNA [PDF]

, 2012
Gene silencing by RNA interference (RNAi) is an important research tool in many areas of biology. To effectively harness the power of this technique in order to explore tick functional genomics and tick-microorganism interactions, optimised parameters ...
A-C Barnard, AA Latif, AE Lew-Tabor, Alain Kohl, AM Nijhof, AM Nijhof, CL Donald, DE Brackney, EF Blouin, EM Morazzani, Esther Schnettler, F Jongejan, G Attarzadeh-Yazdi, G Barry, Gerald Barry, GJ Hannon, I Sifuentes-Romero, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, JC Clemens, JC Scott, JE George, JH Pedra, John K. Fazakerley, K Kiiver, KM Kocan, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Song, Lesley Bell-Sakyi, MGR Varma, P Liljestrom, P Lingor, P Willadsen, Pilar Alberdi, R Fragkoudis, R Fragkoudis, RA Zambon, S Bivalkar-Mehla, S Garcia, S Garcia, S Kurscheid, S Narasimhan, Sabine Weisheit, SM Hammond, SW Ding, TJ Kurtti, TJ Kurtti, UG Munderloh, V Nene, V Shkap, Z Zivkovic, Z Zivkovic   +57 more
core   +4 more sources

Visible gland constantly traces virus-induced gene silencing in cotton

Frontiers in Plant Science, 2022
A virus-induced gene silencing (VIGS) system was established to induce endogenous target gene silencing by post-transcriptional gene silencing (PTGS), which is a powerful tool for gene function analysis in plants.
Zhanfeng Si, Huaitong Wu, Huaitong Wu, Yue Tian, Zhiyuan Zhang, Tianzhen Zhang, Tianzhen Zhang, Yan Hu, Yan Hu   +8 more
doaj   +1 more source

TRUE Gene Silencing

International Journal of Molecular Sciences, 2022
TRUE gene silencing is an RNA-mediated gene expression control technology and is termed after tRNase ZL-utilizing efficacious gene silencing. In this review, I overview the potentiality of small guide RNA (sgRNA) for TRUE gene silencing as novel therapeutics.
openaire   +2 more sources

Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction.

PLoS Genetics, 2022
Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-specific nucleation sites, is critical for stable gene silencing.
R A Greenstein, Henry Ng, Ramon R Barrales, Catherine Tan, Sigurd Braun, Bassem Al-Sady   +5 more
doaj   +1 more source

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles [PDF]

, 2008
Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate
De Smedt, Stefaan, Demeester, Jo, Lentacker, Ine, Sanders, Niek, Vandenbroucke, Roosmarijn   +4 more
core   +1 more source

MIGS as a Simple and Efficient Method for Gene Silencing in Rice

Frontiers in Plant Science, 2018
MiRNA-induced gene silencing (MIGS) technology is a special kind of RNA interference technology that uses miR173 to mediate the production of trans-acting siRNA (ta-siRNA) to achieve target gene silencing.
Xuelian Zheng, Lijia Yang, Qian Li, Linyi Ji, Aiting Tang, Lili Zang, Kejun Deng, Jianping Zhou, Yong Zhang   +8 more
doaj   +1 more source

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.

Journal of the American Chemical Society, 2014
Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery of the siRNA to hepatocytes in vitro and in vivo.
Jayaprakash K Nair, J. Willoughby, A. Chan, K. Charissé, Md. Rowshon Alam, Qianfan Wang, M. Hoekstra, P. Kandasamy, A. Kel'in, S. Milstein, Nate Taneja, Jonathan O’Shea, Sarfraz Shaikh, Ligang Zhang, R. J. van der Sluis, M. Jung, Akin Akinc, R. Hutabarat, S. Kuchimanchi, K. Fitzgerald, Tracy S. Zimmermann, T. V. van Berkel, M. Maier, K. G. Rajeev, M. Manoharan   +24 more
semanticscholar   +1 more source

Virus Recovery Is Induced in Brome mosaic virus p2 Transgenic Plants Showing Synchronous Complementation and RNA-2-Specific Silencing

Molecular Plant-Microbe Interactions, 2000
Nicotiana benthamiana plants expressing Brome mosaic virus (BMV) p2 protein complemented replication of RNAs1+3 but, surprisingly, supported little or no replication of RNA-2. Despite this, the p2 transgenic plants were able to support systemic migration
Lakshminarayan M. Iyer, Timothy C. Hall
doaj   +1 more source

Transgene Was Silenced in Hybrids between Transgenic Herbicide-Resistant Crops and Their Wild Relatives Utilizing Alien Chromosomes

Plants, 2022
The commercialization of transgenic herbicide-resistant (HR) crops may cause gene flow risk. If a transgene in progenies of transgenic crops and wild relatives is silencing, these progenies should be killed by the target herbicide, thus, the gene flow ...
Zicheng Shao, Lei Huang, Yuchi Zhang, Sheng Qiang, Xiaoling Song   +4 more
doaj   +1 more source

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources