Results 51 to 60 of about 3,183,009 (298)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]
, 2004 The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core +1 more source
Plants, 2022 The commercialization of transgenic herbicide-resistant (HR) crops may cause gene flow risk. If a transgene in progenies of transgenic crops and wild relatives is silencing, these progenies should be killed by the target herbicide, thus, the gene flow ...
Zicheng Shao +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Transcriptional gene silencing in humans [PDF]
, 2016 It has been over a decade since the first observation that small non-coding RNAs can functionally modulate epigenetic states in human cells to achieve functional transcriptional gene silencing (TGS).
Morris, Kevin V, Weinberg, Marc S
core +1 more source
Tertiary siRNAs mediate paramutation in C. elegans.
PLoS Genetics, 2015 In the nematode Caenorhabditis elegans, different small RNA-dependent gene silencing mechanisms act in the germline to initiate transgenerational gene silencing. Piwi-interacting RNAs (piRNAs) can initiate transposon and gene silencing by acting upstream
Alexandra Sapetschnig +3 more
doaj +1 more source
Arabidopsis Small RNAs and Their Targets During Cyst Nematode Parasitism
Molecular Plant-Microbe Interactions, 2008 Plant-parasitic cyst nematodes induce the formation of specialized feeding cells in infected roots, which involves plant developmental processes that have been shown to be influenced by microRNAs (miRNAs) and other small RNAs.
Tarek Hewezi +3 more
doaj +1 more source
F1000Research, 2023 Background: Many studies have demonstrated the utility of machine learning (ML) methods for genomic prediction (GP) of various plant traits, but a clear rationale for choosing ML over conventionally used, often simpler parametric methods, is still ...
Aalt D.J. van Dijk +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Catch Me If You Can! RNA Silencing-Based Improvement of Antiviral Plant Immunity
Viruses, 2019 Viruses are obligate parasites which cause a range of severe plant diseases that affect farm productivity around the world, resulting in immense annual losses of yield.
Fatima Yousif Gaffar, Aline Koch
doaj +1 more source