Results 41 to 50 of about 3,183,009 (298)

Influence of viral genes on the cell-to-cell spread of RNA silencing [PDF]

The turnip crinkle virus-based vector TCV–GFPDCP had been devised previously to study cell-to-cell and long-distance spread of virus-induced RNA silencing.
Hong, Yiguo, Zhou, Yu, Ryabov, Eugene V., Zhang, Xuemei   +3 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Simultaneous gene expression and multi-gene silencing in Zea mays using maize dwarf mosaic virus

BMC Plant Biology, 2021
Background Maize dwarf mosaic virus (MDMV), a member of the genus Potyvirus, infects maize and is non-persistently transmitted by aphids. Several plant viruses have been developed as tools for gene expression and gene silencing in plants. The capacity of
Wenshuang Xie, Dee Marie Marty, Junhuan Xu, Nitika Khatri, Kristen Willie, Wanderson Bucker Moraes, Lucy R. Stewart   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Genetic machinery for RNA silencing and defense against viruses in Citrus

Genetics and Molecular Biology, 2007
RNA silencing mechanisms are conserved throughout eukaryotic evolution, possibly due to their importance in viral resistance and other aspects of cell biology.
Vagner Augusto Benedito, Laura Faria, Juliana Freitas-Astúa, Antonio Figueira   +3 more
doaj   +1 more source

Locus-specific ribosomal RNA gene silencing in nucleolar dominance. [PDF]

PLoS ONE, 2007
The silencing of one parental set of rRNA genes in a genetic hybrid is an epigenetic phenomenon known as nucleolar dominance. We showed previously that silencing is restricted to the nucleolus organizer regions (NORs), the loci where rRNA genes are ...
Michelle S Lewis, Diane J Pikaard, Mikhail Nasrallah, Jed H Doelling, Craig S Pikaard   +4 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

GENE SILENCING

The Professional Medical Journal, 2018
Objectives: Cancer, the most complex group of genetic disorders results due to over expression or mutation of oncogenes/molecules involved in cell signaling pathways. KRAS is an oncogene that encodes a small GTPase protein with two isoforms KRasA & KRasB and is involved in the regulation of cell division.
Samra Hafiz, Ghazala Irshad, Farah Deeba Khan   +2 more
openaire   +2 more sources

PGPR-induced regulation of Zn and Fe transporters in wheat (Triticum aestivum L.) uncovered through integrated genome-wide analysis and functional validation

BMC Plant Biology
Zinc (Zn) and iron (Fe) deficiencies affect more than two billion people globally, particularly in cereal-dependent regions where wheat, despite its high consumption, provides inadequate micronutrient levels.
Faiza Maqbool, Rubab Zahra Naqvi, Raheela Rehman, Imran Amin, Ifrah Imran, Asma Imran   +5 more
doaj   +1 more source

Virus‐induced gene silencing database for phenomics and functional genomics in Nicotiana benthamiana

Plant Direct, 2018
Virus‐induced gene silencing (VIGS) is an important forward and reverse genetics method for the study of gene function in many plant species, especially Nicotiana benthamiana.
Muthappa Senthil‐Kumar, Mingyi Wang, Junil Chang, Venkategowda Ramegowda, Olga del Pozo, Yule Liu, Vanthana Doraiswamy, Hee‐Kyung Lee, Choong‐Min Ryu, Keri Wang, Ping Xu, Joyce Van Eck, Suma Chakravarthy, Savithramma P. Dinesh‐Kumar, Gregory B. Martin, Kirankumar S. Mysore   +15 more
doaj   +1 more source