Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters
Stem Cell Reports, 2017 Rat embryonic stem cells (ESCs) offer the potential for sophisticated genome engineering in this valuable biomedical model species. However, germline transmission has been rare following conventional homologous recombination and clonal selection.
Yaoyao Chen +4 more
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Effect of Blast Exposure on Gene-Gene Interactions [PDF]
arXiv, 2018 Repeated exposure to low-level blast may initiate a range of adverse health problem such as traumatic brain injury (TBI). Although many studies successfully identified genes associated with TBI, yet the cellular mechanisms underpinning TBI are not fully elucidated.
arxiv
Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. [PDF]
, 1989 Arthur Melms +6 more
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Journal of Lipid Research, 2004 Apolipoprotein B (apoB) truncation-specifying mutations cause familial hypobetalipoproteinemia (FHBL). Lipoprotein kinetics studies have shown that production rates of apoB-100 are reduced by 70–80% in heterozygous FHBL humans, instead of the expected 50%
Zhouji Chen +4 more
doaj
Frontiers in Plant Science, 2019 The XPF-ERCC1 complex, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink repair, and homologous ...
Anouchka Guyon-Debast +6 more
doaj +1 more source
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. [PDF]
, 1989 K Nocka +6 more
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A chromosomal position effect on gene targeting in human cells [PDF]
We describe gene targeting experiments involving a human cell line (RAN10) containing, in addition to its endogenous alleles, two ectopic alleles of the interferon-inducible gene 6–16.
Yáñez-Muñoz, Rafael
core +1 more source
Recombinant fragment assay for gene targetting based on the polymerase chain reaction [PDF]
, 1988 H.-S. Kim, O. Smithies
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Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. [PDF]
, 1991 Beverly H. Koller +7 more
openalex +3 more sources
Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene [PDF]
, 1988 John A. Zaia +8 more
openalex +1 more source