Zoonotic DiseasesThe human coronavirus 229E (HCoV-229E) is a member of the human coronavirus family that includes SARS-CoV-2, the causative agent of COVID-19. Developing antiviral strategies and compounds is crucial to treat and prevent HCoV-229E infections and the ...
Yujun Liu +3 more
doaj +1 more source
Supplementary Figure 2 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells [PDF]
, 2023 Feng Sun +5 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
RAPID SOUTHERN BLOT PROTOCOL FOR THE ANALYSIS OF TARGETED MUTAGENESIS IN THE MOUSE IGHG1 LOCUS
Scientific Papers Animal Science and Biotechnologies, 2023 The efficiency of homologous recombination relies on the lenght of the homology arms and the chromatin compactation of the locus. In ES cells the immuoglobulin locu is compacted. Thus, the homologous recombination events occur at a very low frequency.
ALENA A. BENCSIK +3 more
doaj
FastD: fast detection of insecticide target-site insensitive mutations and overexpressed detoxification genes in insect populations from RNA-Seq data [PDF]
, 2020 Longfei Chen +8 more
openalex +1 more source
Supplementary Figure 1 from Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells [PDF]
, 2023 Feng Sun +5 more
openalex +1 more source
microRNAs: new regulatores of biological function in Hevea brasilienis [PDF]
, 2012 Fine regulation of gene expression is partially ensured by microRNAs (miRNAs) in response to external stimuli. They negatively regulate gene expression by targeting the cleavage or inhibit the translation of target messenger RN As (mRNAs).
Chaidamsari, Tetty +5 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Inactivation of the SGS1 and EXO1 Genes Synergistically Stimulates Plasmid Integration in Yeast
Food Technology and Biotechnology, 2005 Different procedures used for targeted genetic manipulations are based on homologous recombination between chromosomal and exogenous DNA. A double-strand break (DSB) present on the plasmid molecule stimulates and directs plasmid integration to the ...
Anamarija Štafa +2 more
doaj