Results 151 to 160 of about 12,501,640 (402)

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. [PDF]

, 1989
K Nocka, S Majumder, Benoı̂t Chabot, Prabir Ray, Mario Cervone, Alan Bernstein, Peter Besmer   +6 more
openalex   +1 more source

Lipofection improves gene targeting efficiency in E14 TG2a mouse embryonic stem cells [PDF]

, 2009
Electroporation has been the method of election for transfection of murine embryonic stem cells for over 15 years; however, it is a time consuming protocol because it requires large amounts of DNA and cells, as well as expensive and delicate equipment ...
ALONSO MORALES, ROGELIO ALEJANDRO, ALONSO MORALES, ROGELIO ALEJANDRO, BARBABOSA PLIEGO, ALBERTO, BARBABOSA PLIEGO, ALBERTO, Cajero Juárez, Marcos, Cajero Juárez, Marcos, LOPEZ HEYDECK, SANDRA MARICRUZ, LOPEZ HEYDECK, SANDRA MARICRUZ, MARTINEZ CASTAÑEDA, JOSE SIMON, MARTINEZ CASTAÑEDA, JOSE SIMON, Robles González, Jose Francisco, Robles González, Jose Francisco, VAZQUEZ CHAGOYAN, JUAN CARLOS, VAZQUEZ CHAGOYAN, JUAN CARLOS   +13 more
core  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Microglia targeting by adeno-associated viral vectors

Frontiers in Immunology
Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain’s inflammatory response to stress.
Maria Stamataki, Björn Rissiek, Tim Magnus, Jakob Körbelin   +3 more
doaj   +1 more source

Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene. [PDF]

, 1983
Philippe Soriano, J.W. Dijkstra, A. Legrand, H H Spanjer, D. Londos-Gagliardi, Frits H. Roerdink, Gerrit L. Scherphof, C. Nicolau   +7 more
openalex   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

An Engineered RNase P Ribozyme Effectively Reduces Human Coronavirus 229E Gene Expression and Growth in Human Cells

Zoonotic Diseases
The human coronavirus 229E (HCoV-229E) is a member of the human coronavirus family that includes SARS-CoV-2, the causative agent of COVID-19. Developing antiviral strategies and compounds is crucial to treat and prevent HCoV-229E infections and the ...
Yujun Liu, Bin Yan, Hao Gong, Fenyong Liu   +3 more
doaj   +1 more source

Recombinant fragment assay for gene targetting based on the polymerase chain reaction [PDF]

, 1988
H.-S. Kim, O. Smithies
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source