Results 151 to 160 of about 12,185,719 (426)
Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II
eJournal of Oral Maxillofacial Research, 2011 Objectives: Cancer is the product of alterations in oncogenes, tumour suppressor genes and most recently microRNA genes not as a single event or single change but rather as a multistep process.
Antonia Kolokythas +2 more
doaj
Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function
Cell Reports, 2017 BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here, we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity
Victoria E. Mgbemena +5 more
doaj +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Mechanisms of Development, 2011 The products of the Cdx genes, Cdx1, Cdx2 and Cdx4, play multiple roles in early vertebrate development, and have been proposed to serve to relay signaling information from Wnt, RA and FGF pathways to orchestrate events related to anterior-posterior vertebral patterning and axial elongation.
Joanne G.A. Savory +3 more
openaire +3 more sources
Genome Research, 2013 Improved methods for engineering sequence-specific nucleases, including zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs), have made it possible to precisely modify plant genomes.
Yiping Qi +7 more
semanticscholar +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
A Myelin Proteolipid Protein-LacZ Fusion Protein Is Developmentally Regulated and Targeted to the Myelin Membrane in Transgenic Mice [PDF]
, 1993 Transgenic mice were generated with a fusion gene carrying a portion of the murine myelin proteolipid protein (PLP) gene, including the first intron, fused to the E. coli LacZ gene.
Duchala, Cynthia S. +3 more
core +2 more sources
Inferring Disease and Gene Set Associations with Rank Coherence in Networks [PDF]
arXiv, 2011 A computational challenge to validate the candidate disease genes identified in a high-throughput genomic study is to elucidate the associations between the set of candidate genes and disease phenotypes. The conventional gene set enrichment analysis often fails to reveal associations between disease phenotypes and the gene sets with a short list of ...
arxiv
Targeted gene repair – in the arena [PDF]
Journal of Clinical Investigation, 2003 The development of targeted gene repair is under way and, despite some setbacks, shows promise as an alternative form of gene therapy. This approach uses synthetic DNA molecules to activate and direct the cell's inherent DNA repair systems to correct inborn errors.
openaire +3 more sources
Gene targeting in plants: 25 years later.
International Journal of Developmental Biology, 2013 Only five years after the initiation of transgenic research in plants, gene targeting (GT) was achieved for the first time in tobacco. Unfortunately, the frequency of targeted integration via homologous recombination (HR) was so low in comparison to ...
H. Puchta, Friedrich Fauser
semanticscholar +1 more source