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Targeting Trichothecene Biosynthetic Genes [PDF]
, 2016 Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong +4 more
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Targeted gene regulation and gene ablation
Trends in Endocrinology & Metabolism, 2001Investigations of the mechanisms involved in appropriate, developmentally regulated tissue-specific gene transcription have laid the foundations for transgenic and gene-therapy technologies directing specific induction or ablation of genes of interest in a tissue-restricted manner.
Sophia Y. Tsai, Francesco J. DeMayo
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2009
Gene targeting in mice has been used extensively to elucidate gene function in vivo. However, for gene targeting to be successful, the targeting vector must be carefully designed. This chapter addresses the rationale behind designing targeting vectors, detailing the essential components, and highlighting specific considerations for different types of ...
J. Simon, Victoria A. McGuire, C. Arthur
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Gene targeting in mice has been used extensively to elucidate gene function in vivo. However, for gene targeting to be successful, the targeting vector must be carefully designed. This chapter addresses the rationale behind designing targeting vectors, detailing the essential components, and highlighting specific considerations for different types of ...
J. Simon, Victoria A. McGuire, C. Arthur
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BioEssays, 1994
AbstractMice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated.
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AbstractMice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated.
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Inducible Gene Targeting in Mice
Science, 1995A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase β gene flanked by IoxP recombinase recognition sites ...
Kuhn, R. +3 more
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Antibodies for targeted gene therapy: extracellular gene targeting and intracellular expression
Advanced Drug Delivery Reviews, 1998Antibody genes of human origin and human antibodies directed against human proteins have become widely available in recent years. These are valuable reagents for gene therapy applications, in which the use of human proteins and genes allows for increased therapeutic benefit. Engineered human antibodies can be used in gene therapy both as a component of
Wayne A. Marasco, Susan Dana Jones
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Gene Targeting for Gene Therapy: Prospects
Molecular Genetics and Metabolism, 1999Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Advances in Targeted Gene Delivery
Current Drug Delivery, 2019Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g.
Ara Begum, Anjuman +3 more
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Gene targeting of retinoid receptors
Molecular Biotechnology, 1998Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome.
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Targeting Ochratoxin Biosynthetic Genes
2016The pathway of ochratoxin A (OTA) biosynthesis has not yet been completely elucidated. Essentially, two kind of genes have been demonstrated to be involved in the biosynthesis of OTA. One of them is the nrps gene encoding a non-ribosomal peptide synthetase (NRPS) which catalyzes the ligation between the isocoumarin group, constituting the polyketide ...
Gallo Antonia, Perrone Giancarlo
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