Results 191 to 200 of about 1,756,365 (358)

SSA-mediated selection marker gene activation enhances relative gene targeting efficiency in plants. [PDF]

Hortic Res
Kong D, Cheng Y, Ke Y, Dang X, Liu X, Wang C, Huang C, Ye R, Miki D.   +8 more
europepmc   +1 more source

Gene targeting techniques for Huntington's disease. [PDF]

Ageing Res Rev, 2021
Fields E, Vaughan E, Tripu D, Lim I, Shrout K, Conway J, Salib N, Lee Y, Dhamsania A, Jacobsen M, Woo A, Xue H, Cao K.   +12 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The primer sequences of targeted genes.

Arghavan Zebardast (21601107), Kaveh Sadeghi (12488183), Ahmad Nejati (11853467), Sevrin Zadheidar (21601110), Mohammad Hossein Najmi (21601113), Adel Abedi (12488186), Vahid Salimi (475780), Mehdi Shabani (11921197), Jila Yavarian (12488177), Nazanin Zahra Shafiei Jandaghi (12488180), Talat Mokhtari Azad (20325378)   +10 more
openalex   +1 more source

Evolutionarily Dynamic, but Robust, Targeting of Resistance Genes by the miR482/2118 Gene Family in the Solanaceae [PDF]

, 2015
Sophie de Vries, Thorsten Kloesges, Laura Rose   +2 more
openalex   +1 more source

Novel Therapies in Advanced Pancreatic Cancer: A Peak Beyond the Realms of Gene Targeting. [PDF]

Cureus
Dave P, Beriwala V, Parikh C, Uddin A, Dayala H, Patel RH, Chirumamilla PC, Winer A.   +7 more
europepmc   +1 more source

Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting. [PDF]

Anim Cells Syst (Seoul), 2022
Jeong YJ, Cho J, Kwak J, Sung YH, Kang BC.   +4 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Colocalization and causal analysis results for blood genes and the target trait.

Ningning Liu (292952), Yi Hou (148620), Miao Yu (199182), Gaihong Liu (21453747), Yingxue Xu (3839467), Qiang Jiang (764314), Dongli Wang (211889), Lianzhu Wang (21453750), Yujie Zhao (285521)   +8 more
openalex   +1 more source

Lethality rescue and long-term amelioration of a citrullinemia type I mouse model by neonatal gene-targeting combined to SaCRISPR-Cas9. [PDF]

Mol Ther Methods Clin Dev, 2023
Lisjak M, Iaconcig A, Guarnaccia C, Vicidomini A, Moretti L, Collaud F, Ronzitti G, Zentilin L, Muro AF.   +8 more
europepmc   +1 more source