DeepGDel: Deep Learning-based Gene Deletion Prediction Framework for Growth-Coupled Production in Genome-Scale Metabolic Models [PDF]
arXivIn genome-scale constraint-based metabolic models, gene deletion strategies are crucial for achieving growth-coupled production, where cell growth and target metabolite production are simultaneously achieved. While computational methods for calculating gene deletions have been widely explored and contribute to developing gene deletion strategy ...
arxiv
The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. [PDF]
, 1994 Robert J. Bohinski +2 more
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Molecular Oncology, EarlyView.This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke +12 more
wiley +1 more source
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. [PDF]
, 1991 Beverly H. Koller +7 more
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Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting. [PDF]
Anim Cells Syst (Seoul), 2022 Jeong YJ +4 more
europepmc +1 more source
ScAtt: an Attention based architecture to analyze Alzheimer's disease at cell type level from single-cell RNA-sequencing data [PDF]
arXivAlzheimer's disease (AD) is a pervasive neurodegenerative disorder that leads to memory and behavior impairment severe enough to interfere with daily life activities. Understanding this disease pathogenesis can drive the development of new targets and strategies to prevent and treat AD.
arxiv
Molecular Oncology, Volume 19, Issue 5, Page 1422-1435, May 2025.The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina +17 more
wiley +1 more source
Opaque-2 is a transcriptional activator that recognizes a specific target site in 22-kD zein genes. [PDF]
, 1992 R J Schmidt +3 more
openalex +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1155-1169, April 2025.We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park +8 more
wiley +1 more source
Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis. [PDF]
PeerJ, 2023 Liu T +5 more
europepmc +1 more source