Results 241 to 250 of about 12,501,640 (402)

Enhancing gene editing and gene targeting efficiencies in Arabidopsis thaliana by using an intron-containing version of ttLbCas12a. [PDF]

Plant Biotechnol J, 2023
Schindele P, Merker L, Schreiber T, Prange A, Tissier A, Puchta H.   +5 more
europepmc   +1 more source

Prenatal specification and target induction underlie the enrichment of calcitonin gene-related peptide in the trigeminal ganglion neurons projecting to the cerebral vasculature [PDF]

, 1990
Kieran Horgan, TP O'Connor, Derek van der Kooy   +2 more
openalex   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Utilizing shRNA-expressing lentivectors for viral hemorrhagic septicemia virus suppression via NV gene targeting. [PDF]

Front Vet Sci
Pourhoseini Dehkordi N, Saffar B, Mokhtari A, Asadi Samani L, Amini A.   +4 more
europepmc   +1 more source

Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis. [PDF]

PeerJ, 2023
Liu T, Zhang B, Gao Y, Zhang X, Tong J, Li Z.   +5 more
europepmc   +1 more source

An Enhanced Gene Targeting Toolkit for Drosophila: Golic+

Genetics, 2015
Hui-Min Chen, Yaling Huang, B. Pfeiffer, Xiaohao Yao, Tzumin Lee   +4 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues. [PDF]

Sci Rep
Majd-Marani S, Eftekhari A, Elias SG, Beffa R, Alebrahim MT, Mishra AP, Afrouz M.   +6 more
europepmc   +1 more source

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety. [PDF]

Bio Protoc, 2023
Tran NT, Lebedin M, Danner E, Kühn R, Rajewsky K, Chu VT.   +5 more
europepmc   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source