Results 261 to 270 of about 12,501,640 (402)

Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning. [PDF]

Mol Med, 2023
Founta K, Dafou D, Kanata E, Sklaviadis T, Zanos TP, Gounaris A, Xanthopoulos K.   +6 more
europepmc   +1 more source

Amplification by the polymerase chain reaction of a specific target sequence in the gene coding for Escherichia coli verotoxin (VTe variant) [PDF]

, 1991
W Johnson
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Editorial: Prevention of viral diseases by gene targeting. [PDF]

Front Genome Ed
Luo F, Wang Q, Chen S.
europepmc   +1 more source

Cre recombinase microinjection for single-cell tracing and localised gene targeting.

Development, 2023
Sendra M, de Dios Hourcade J, Temiño S, Sarabia AJ, Ocaña OH, Domínguez JN, Torres M.   +6 more
europepmc   +1 more source

Gene Targeting to the Cerebral Cortex Following Intranasal Administration of Polyplexes. [PDF]

Pharmaceutics, 2022
Petkova AI, Kubajewska I, Vaideanu A, Schätzlein AG, Uchegbu IF.   +4 more
europepmc   +1 more source

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus [PDF]

, 1992
Chu‐Xia Deng, Mario R. Capecchi
openalex   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Cas12a-mediated gene targeting by sequential transformation strategy in Arabidopsis thaliana. [PDF]

BMC Plant Biol
Li J, Wei Q, Cheng Y, Kong D, Kong Z, Ke Y, Dang X, Zhu JK, Shimada H, Miki D.   +9 more
europepmc   +1 more source

A New EBS2b-IBS2b Base Paring (A_-8/T_-8) Improved the Gene-Targeting Efficiency of Thermotargetron in Escherichia coli. [PDF]

Microbiol Spectr, 2023
Cui G, Hua D, Zhao X, Zhou J, Yang Y, Huang T, Wang X, Zhao Y, Zhang T, Liao J, Guan Z, Luo P, Chen Z, Qi X, Hong W.   +14 more
europepmc   +1 more source