Results 261 to 270 of about 1,717,717 (307)

Gene Targeting for Gene Therapy: Prospects

Molecular Genetics and Metabolism, 1999
Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Targeting Fumonisin Biosynthetic Genes

2016
The fungus Fusarium is an agricultural problem because it can cause disease on most crop plants and can contaminate crops with mycotoxins. There is considerable variation in the presence/absence and genomic location of gene clusters responsible for synthesis of mycotoxins and other secondary metabolites among species of Fusarium.
Robert H, Proctor, Martha M, Vaughan
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Conventional Murine Gene Targeting

2013
Murine gene knockout models engineered over the last two decades have continued to demonstrate their potential as invaluable tools in understanding the role of gene function in the context of normal human development and disease. The more recent elucidation of the human and mouse genomes through sequencing has opened up the capability to elucidate the ...
Albert G, Zimmermann, Yue, Sun
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Gene therapy targets XLP

Blood, 2013
Studying a murine model of X-linked lymphoproliferative syndrome (XLP), Rivat et al report in this issue of Blood that the immune function defects of the disorder are improved or corrected by lentiviral vector–mediated gene transfer of SH2D1A into autologous hematopoietic stem cells.[1][1] X-
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Target Genes: Bone Proteins

2005
http://www.elsevier.com/wps/find/bookdescription.cws_home/703914/description ...
Atkins, G., Findlay, D., Anderson, P., Morris, H.   +3 more
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Targeting Aflatoxin Biosynthetic Genes

2016
Chemical detoxification and physical destruction of aflatoxins in foods and feed commodities are mostly unattainable in a way that preserves the edibility of the food. Therefore, preventing mycotoxins in general and aflatoxins in particular from entering the food chain is a better approach.
Ali Y, Srour, Ahmad M, Fakhoury, Robert L, Brown   +2 more
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Targeting Ochratoxin Biosynthetic Genes

2016
The pathway of ochratoxin A (OTA) biosynthesis has not yet been completely elucidated. Essentially, two kind of genes have been demonstrated to be involved in the biosynthesis of OTA. One of them is the nrps gene encoding a non-ribosomal peptide synthetase (NRPS) which catalyzes the ligation between the isocoumarin group, constituting the polyketide ...
Gallo Antonia, Perrone Giancarlo
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Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Nature Reviews Drug Discovery, 2021
Oliver Soehnlein, Peter Libby
exaly  

AAV-Mediated Gene Targeting

2011
The precise alteration of sequences by homologous recombination is an important strategy for gene therapies as well as investigating gene function and cellular DNA repair pathways. Inefficient delivery of template DNA to the nucleus using transfection or electroporation methods is one limitation of the frequency of homologous recombination in primary ...
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Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

Nature Reviews Clinical Oncology, 2021
Lukas Kraehenbuehl, Chien-Huan Weng, Shabnam Eghbali   +2 more
exaly