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Gene Targeting for Gene Therapy: Prospects
Molecular Genetics and Metabolism, 1999Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Targeting Trichothecene Biosynthetic Genes
2016Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong +4 more
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Gene targeting in hemostasis. plasminogen
Frontiers in Bioscience, 2001A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice.
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Gene targeting of retinoid receptors
Molecular Biotechnology, 1998Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome.
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1999
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications.
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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications.
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The fate and targeting engineering of crossover vesicle-based gene delivery system
Advanced Drug Delivery Reviews, 2022Jianqing Gao +2 more
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Heritable gene targeting in zebrafish using customized TALENs
Nature Biotechnology, 2011Xiao An, Bo Zhang, Mingguo Zhou
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Efficient Gene Targeting in Maize Using Inducible CRISPR-Cas9 and Marker-free Donor Template
Molecular Plant, 2020Sandeep Kumar +2 more
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