Results 271 to 280 of about 1,734,183 (310)
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BioEssays, 1994
AbstractMice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated.
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AbstractMice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated.
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Gene Targeting for Gene Therapy: Prospects
Molecular Genetics and Metabolism, 1999Ideally, gene therapy involves the correction of genetic defects through the natural means of gene targeting. This therapy possesses a number of conceptual advantages. However, a major obstacle to successful gene therapy is the relative inefficiency of the targeting process in mammalian cells.
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Gene targeting in hemostasis. plasminogen
Frontiers in Bioscience, 2001A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice.
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Targeting Trichothecene Biosynthetic Genes
2016Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR. Qualitative PCRs are used to assign chemotypes to individual isolates, e.g., the capacity to produce type A and/or type B trichothecenes. Many regions in the core cluster (consisting of 12 genes) including intergenic regions have been
Wei, Songhong +4 more
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1999
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications.
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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications.
openaire +1 more source
Gene targeting of retinoid receptors
Molecular Biotechnology, 1998Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome.
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The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system
Advanced Drug Delivery Reviews, 2022Jian-Qing Gao, Tianyuan Zhang
exaly
Heritable gene targeting in zebrafish using customized TALENs
Nature Biotechnology, 2011An Xiao, Zuoyan Zhu, Bo Zhang
exaly
Knockout mice created by TALEN-mediated gene targeting
Nature Biotechnology, 2013Young Hoon Sung +2 more
exaly