Results 271 to 280 of about 12,501,640 (402)

Opaque-2 is a transcriptional activator that recognizes a specific target site in 22-kD zein genes.

, 1992
R J Schmidt, Mariena Ketudat‐Cairns, Milo J. Aukerman, Gisela Hoschek   +3 more
openalex   +1 more source

GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. [PDF]

, 1994
A L Wu, W. Scott Moye‐Rowley
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Recent Progress in Gene-Targeting Therapies for Spinal Muscular Atrophy: Promises and Challenges. [PDF]

Genes (Basel)
Haque US, Yokota T, Yokota T.
europepmc   +1 more source

Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies. [PDF]

Int J Mol Sci, 2022
Chamakioti M, Karantzelis N, Taraviras S.   +2 more
europepmc   +1 more source

Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer [PDF]

, 1992
Marco Bregni, Michele Magni, Salvatore Siena, Massimo Di Nicola, Gianni Bonadonna, AM Gianni   +5 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

An efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum. [PDF]

AMB Express
Ishii M, Yamada T, Ohata S.
europepmc   +1 more source

Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting. [PDF]

PLoS One, 2021
Lassègue B, Kumar S, Mandavilli R, Wang K, Tsai M, Kang DW, Demos C, Hernandes MS, San Martín A, Taylor WR, Jo H, Griendling KK.   +11 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source