Results 81 to 90 of about 708,347 (229)
Functional analysis of a gene locus in response to non-canonical combinations of transcription factors [PDF]
arXiv, 2023 Transcription factor combinations determine gene locus activity and thereby cell identity. However, the precise link between concentrations of such activating transcription factors and target-gene activity is ambiguous. Here we investigate this link for the gap gene dependent activation of the even-skipped (eve) locus in the Drosophila embryo.
arxiv
Targeted genome modifications in soybean with CRISPR/Cas9 [PDF]
, 2015 Background: The ability to selectively alter genomic DNA sequences in vivo is a powerful tool for basic and applied research. The CRISPR/Cas9 system precisely mutates DNA sequences in a number of organisms.
Jacobs, Thomas +3 more
core +2 more sources
Journal of Lipid Research, 1999 In subjects with familial hypobetalipoproteinemia heterozygous for truncated forms of apolipoprotein B, both apoB-100 and the truncated forms are produced at lower than expected rates.
Rai Ajit K. Srivastava +4 more
doaj
Lack of RNA-DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos [PDF]
, 2005 There are numerous reports of the use of RNA-DNA oligonucleoticles (chimeraplasts) to correct point mutations in vitro and in vivo, including the human apolipoprotein E gene (ApoE).
Owen, JS, Simons, JP, Tagalakis, AD
core +1 more source
A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis
BiomedicinesBackground: Protein kinase D3 (PKD3) is a member of the PKD family that has been implicated in many intracellular signalling pathways. However, defined statements regarding PKD isoform specificity and in vivo functions are rare.
Ursula Braun, Michael Leitges
doaj +1 more source
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. [PDF]
, 2019 BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Bates, Sofie L +8 more
core +2 more sources
Search for basonuclin target genes [PDF]
Biochemical and Biophysical Research Communications, 2006 Basonuclin (Bnc 1) is a transcription factor that has an unusual ability to interact with promoters of both RNA polymerases I and II. The action of basonuclin is mediated through three pairs of evolutionarily conserved zinc fingers, which produce three DNase I footprints on the promoters of rDNA and the basonuclin gene. Using these DNase footprints, we
Zhang, S, Tseng, H, Schultz, RM, Wang, J
openaire +5 more sources
Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease
Disease Models & Mechanisms, 2020 Animal models of human disease provide an in vivo system that can reveal molecular mechanisms by which mutations cause pathology, and, moreover, have the potential to provide a valuable tool for drug development. Here, we have developed a zebrafish model
Gideon L. Hughes +5 more
doaj +1 more source
Targeting kidney mesangium by nanoparticles of defined size [PDF]
, 2011 Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of ...
C. H. J. Choi +19 more
core +2 more sources
Mining Functionally Related Genes with Semi-Supervised Learning [PDF]
arXiv, 2020 The study of biological processes can greatly benefit from tools that automatically predict gene functions or directly cluster genes based on shared functionality. Existing data mining methods predict protein functionality by exploiting data obtained from high-throughput experiments or meta-scale information from public databases.
arxiv