Results 91 to 100 of about 4,362,156 (310)
Screening for coping style increases the power of gene expression studies [PDF]
, 2009 <b>Background:</b> Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges.
Pilarczyk, Maciej +22 more
core +2 more sources
Frontiers in Plant Science, 2019 The XPF-ERCC1 complex, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink repair, and homologous ...
Anouchka Guyon-Debast +6 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Myostatin gene targeting in cultured China Han ovine myoblast cells
Animal, 2007 Myostatin (MSTN), a member of the transforming growth factor-β superfamily, has been shown to be a negative regulator of myogenesis. Natural mutation in beef cattle causes double-muscling phenotypes.
L. Zhang, X. Yang, X. An, Y. Chen
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Review of MicroRNA Proposed Target Genes in Oral Cancer. Part II
eJournal of Oral Maxillofacial Research, 2011 Objectives: Cancer is the product of alterations in oncogenes, tumour suppressor genes and most recently microRNA genes not as a single event or single change but rather as a multistep process.
Antonia Kolokythas +2 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Targeting Amyotrophic Lateral Sclerosis with Gene Therapy: From Silencing Genes to Enhancing Neuroprotection [PDF]
Elivery routes; Gene augmentation; Gene silencingVies d'administració; Augment gènic; Silenciament gènicVías de administración; Aumento génico; Silenciamiento génicoGene therapy is emerging as a transformative approach for treating amyotrophic lateral ...
Verdés-Franquesa, Sergi +2 more
core +1 more source
Nuclear Targeting Dynamics of Gold Nanoclusters for Enhanced Therapy of HER2(+) Breast Cancer [PDF]
, 2011 Recent advances in fluorescent metal nanoclusters have spurred tremendous interest In nanomedicine due to the ease of fabrication, excellent biocompatibility, and, more Importantly, excellent wavelength-dependent tunability.
Joseph Irudayaraj +5 more
core +1 more source