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Gene transfer techniques for cardiac arrhythmias

open access: yesAnnals of Medicine, 2004
Therapy for cardiac arrhythmias is inadequate, based on current options. Gene therapy has shown tremendous potential to investigate pathophysiology and potential therapies for cardiac diseases. The current work reviews the possibilities for application of in vivo gene transfer to treatment of common arrhythmias, including vector selection, delivery ...
J Kevin Donahue   +2 more
exaly   +3 more sources
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Techniques for gene transfer into neurons

Current Opinion in Neurobiology, 2002
To illuminate the function of the thousands of genes that make up the complexity of the nervous system, it is critical to be able to introduce and express DNA in neurons. Over the past two decades, many gene transfer methods have been developed, including viral vectors, liposomes and electroporation.
Philip Washbourne   +1 more
exaly   +3 more sources

Lymphocyte apoptosis: induction by gene transfer techniques [PDF]

open access: yesGene Therapy, 1997
Efficient gene transfer of lymphocytes has been shown to be extremely difficult. The molecular background for this gene transfer resistance is not completely understood. We reasoned that apoptosis may play a role in this gene transfer resistance of lymphocytes.
P Lefterova   +2 more
exaly   +3 more sources

A review of gene transfer techniques

The American Journal of Surgery, 1993
The ability to transfer genetic material from one cell to another provides a novel approach for the investigation and potential treatment of a variety of diseases. Several gene transfer techniques have been developed. Of these, the use of retroviruses as vectors has allowed highly efficient and stable introduction of foreign genes into target mammalian
P C, Watt, M P, Sawicki, E, Passaro
openaire   +2 more sources

Gene transfer and antisense nucleic acid techniques

Parasitology Today, 1994
Attempts to suppress a harmful genetic trait by antisense means, or to restore a normal phenotype by gene transfer, attract much publicity. This is especially the case where clinical trials incorporating such methodologies have been initiated, such as antisense oligonucleotide therapies for some types of leukaemia, antisense gene-transfer therapy for a
N, Miller, R G, Vile
openaire   +2 more sources

Gene-transfer and plant-regeneration (techniques)

Trends in Biotechnology, 1995
The production of transgenic plants depends on the stable introduction of foreign DNA into the plant genome, followed by regeneration to produce intact plants, and the subsequent expression of the introduced gene(s). A variety of transformation methods have been developed, and this has allowed many of the world's important crop plants to be transformed.
Richard Walden, Ruth Wingender
openaire   +1 more source

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