Results 111 to 120 of about 78,545 (352)

Considerations for Issues of Regression to the Mean and Contextual Effects in Clinical Trials for Pain in Rheumatic Diseases

Arthritis Care &Research, EarlyView.
Recently, there has been growing discussion about how to best assess pain in clinical trials in rheumatic diseases. Reliable measurement of pain outcomes is essential for accurately determining the effectiveness of treatments. Although pain intensity is the most common measure of change in pain trials, other pain‐related measures, such as pain ...
Yen T. Chen, Guohao Zhu, Afton L. Hassett, Daniel Clauw, Susan L. Murphy   +4 more
wiley   +1 more source

Knee crepitus and osteoarthritis features in young adults following traumatic knee injury

Arthritis Care &Research, Accepted Article.
Objective This study explored the association between knee crepitus and the presence, and worsening, of structural osteoarthritis features and self‐reported outcomes in young adults following traumatic knee injury. Methods One‐year following anterior cruciate ligament reconstruction (ACLR), 112 participants (41 female participants; median age 28 years)
Jamon L Couch, Brooke E Patterson, Kay M Crossley, Ali Guermazi, Matthew G King, Danilo De Oliveira Silva, Jackie L Whittaker, Michael A Girdwood, Adam G Culvenor   +8 more
wiley   +1 more source

The effects of general anesthetics on mitochondrial structure and function in the developing brain. [PDF]

Front Neurol, 2023
Hogarth K, Tarazi D, Maynes JT.
europepmc   +1 more source

THE USE OF ETHYL CHLORID AS A GENERAL ANESTHETIC IN GYNECOLOGY. [PDF]

, 1904
Elizabeth Montgomery
openalex   +1 more source

Periodic solutions and refractory periods in the soliton theory for nerves and the locust femoral nerve

, 2010
Close to melting transitions it is possible to propagate solitary electromechanical pulses which reflect many of the experimental features of the nerve pulse including mechanical dislocations and reversible heat production.
Abbott, Andersen, Andrei Ludu, Andrew D. Jackson, Coillot, Cole, Ebel, Edgar Villagran Vargas, Eichmann, Evans, FitzHugh, Halstenberg, Halstenberg, Heimburg, Heimburg, Heimburg, Heimburg, Heimburg, Heimburg, Heitler, Hodgkin, Hodgkin, Howarth, Howarth, Hustert, Iwasa, Iwasa, Kaufmann, Kobatake, Lautrup, Mitaku, Mücke, Nagumo, Peter Gumrich, Reinhold Hustert, Remoissenet, Ritchie, Ruiz-Sanz, Schrader, Tasaki, Tasaki, Tasaki, Tasaki, Tasaki, Thomas Heimburg, Wilke, Wilke   +46 more
core   +1 more source

Perceptions about asymptomatic hyperuricemia and views about urate‐lowering therapy in people with asymptomatic hyperuricemia

Arthritis Care &Research, Accepted Article.
Background/Aims Asymptomatic hyperuricemia is a precursor of gout and is also associated with cardiovascular disease and chronic kidney disease. The aim of this study was to understand perceptions about asymptomatic hyperuricemia and views about urate‐lowering therapy in people with asymptomatic hyperuricemia.
Nicola Dalbeth, Sarah Stewart, Gregory D Gamble, Borislav Mihov, Lisa K Stamp, Janine Haslett, William J Taylor, Tony R Merriman, Adwoa Dansoa Tabi‐Amponsah, Anne Horne, Tuhina Neogi, Tristan Pascart, Mariano Andrés, Maria‐Luisa Peral‐Garrido, Eleonora Norkuviene, Janitzia Vazquez Mellado, Till Uhlig, Mingshu Sun, Changgui Li, Keith J Petrie   +19 more
wiley   +1 more source

Taking a Deep Dive into Lipid-Based Mechanisms of General Anesthetics. [PDF]

Biochemistry, 2023
Regen SL.
europepmc   +1 more source

Structure and Dynamics of Brain Lobes Functional Networks at the Onset of Anesthesia Induced Loss of Consciousness

, 2016
Anesthetic agents are neurotropic drugs able to induce dramatic alterations in the thalamo-cortical system, promoting a drastic reduction in awareness and level of consciousness.
Padovani, Eduardo C.
core  

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]

, 2019
Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L, Bergese, Sergio D, Berkowitz, Richard D, Brzezinski, Marek, Cochrane, Kristina, Habib, Ashraf S, Hammer, Gregory B, Mace, Sharon E, Minkowitz, Harold S, Pan, Peter H, Wase, Linda   +10 more
core  

Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. [PDF]

, 2020
Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.
Cao, Jimin, Christopher, Theodore, Gao, Erhe, Guo, Rui, Jiao, Liyuan, Lau, Wayne Bond, Lopez, Bernard, Ma, Xin-Liang, Wang, Yajing, Xie, Dina, Zhang, Yanqing, Zhao, Jianli   +11 more
core   +1 more source