General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep [PDF]
Medicina, 2022 Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread.
John Michael Bonvini
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The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
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Shared structural mechanisms of general anaesthetics and benzodiazepines. [PDF]
Nature, 2020 Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA A ) receptors to dampen neuronal activity in the brain 1 – 5 .
Kim JJ +9 more
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How general anesthetics work: from the perspective of reorganized connections within the brain [PDF]
Korean Journal of Anesthesiology, 2022 General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood.
Teo Jeon Shin +2 more
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General anesthetics activate a potent central pain-suppression circuit in the amygdala. [PDF]
Nat Neurosci, 2020 General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits.
Hua T +10 more
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Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]
Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages
537-545, 2016 Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
Brooks, NJ +7 more
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General Anesthetics on Immune System Cytokines: A Narrative Review Article. [PDF]
Anesth Pain Med, 2020 Context According to the previous studies, general anesthesia influences the immune system. Evaluating such impacts on the immune system helps to improve the management of anesthesia.
Jafarzadeh A +4 more
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Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. [PDF]
Nat Commun, 2020 Metastasis can occur following surgical resection of solid tumors and metastasis is the main cause of cancer death. The role of anesthetics used during surgery in cancer metastasis and the underlying mechanism remains largely unknown.
Li R, Huang Y, Lin J.
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General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics [PDF]
PharmaceuticalsThe introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková +2 more
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High-Loading Self-Assembling Peptide Nanoparticles as a Lipid-Free Carrier for Hydrophobic General Anesthetics [PDF]
International Journal of Nanomedicine, 2021 Jing Liu,1,2 Fei Peng,1,2 Yi Kang,1,2 Deying Gong,1,2 Jing Fan,1,2 Wensheng Zhang,1,2 Feng Qiu1,2 1Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan ...
Liu J +6 more
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