The Effects of General Anesthetics on Synaptic Transmission. [PDF]
Curr Neuropharmacol, 2020 General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis ...
Hao X +9 more
europepmc +6 more sources
Mechanisms of action of general anesthetics
Frontiers in Bioscience - Landmark, 2014 Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive ...
F Ellinghaus
exaly +5 more sources
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
arxiv +4 more sources
Shared structural mechanisms of general anaesthetics and benzodiazepines. [PDF]
Nature, 2020 Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA A ) receptors to dampen neuronal activity in the brain 1 – 5 .
Kim JJ +9 more
europepmc +2 more sources
General anesthetics activate a potent central pain-suppression circuit in the amygdala. [PDF]
Nat Neurosci, 2020 General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits.
Hua T +10 more
europepmc +2 more sources
How general anesthetics work: from the perspective of reorganized connections within the brain [PDF]
Korean Journal of Anesthesiology, 2022 General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood.
Teo Jeon Shin +2 more
doaj +2 more sources
General Anesthetics on Immune System Cytokines: A Narrative Review Article. [PDF]
Anesth Pain Med, 2020 Context According to the previous studies, general anesthesia influences the immune system. Evaluating such impacts on the immune system helps to improve the management of anesthesia.
Jafarzadeh A +4 more
europepmc +2 more sources
Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. [PDF]
Nat Commun, 2020 Metastasis can occur following surgical resection of solid tumors and metastasis is the main cause of cancer death. The role of anesthetics used during surgery in cancer metastasis and the underlying mechanism remains largely unknown.
Li R, Huang Y, Lin J.
europepmc +2 more sources
Stabilizing membrane domains antagonizes n-alcohol anesthesia [PDF]
Biophysical Journal, Volume 111, Issue 3, 9 August 2016, Pages
537-545, 2016 Diverse molecules induce general anesthesia with potency strongly correlated both with their hydrophobicity and their effects on certain ion channels. We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma membrane derived vesicles by lowering the critical temperature ($T_c$) for phase separation.
Brooks, NJ +7 more
arxiv +5 more sources
General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics [PDF]
PharmaceuticalsThe introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková +2 more
doaj +2 more sources