Results 31 to 40 of about 80,551 (349)

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Frontiers in Synaptic Neuroscience, 2022
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel, Hugh C. Hemmings Jr., Hugh C. Hemmings Jr.   +2 more
doaj   +1 more source

Effect of general anesthetics on the developing brain

Journal of Anaesthesiology Clinical Pharmacology, 2012
Studies on rodents and subhuman primates suggest that prolonged exposure to general anesthetics may induce widespread neuronal cell death and neurological sequelae; seriously questioning the safety of pediatric anesthesia.
S Velayudha Reddy
doaj   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats

Frontiers in Neurology, 2013
General anesthetics are neurotoxic to neonatal rodents and nonhuman primates. Neonatal exposure to general anesthetics has been associated with long-term cognitive deficits in animal models. Some data from humans are consistent with long-term deleterious
Kathy L Murphy, Mark G Baxter
doaj   +1 more source

Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia [PDF]

, 2001
Direct current auditory evoked potentials (DC-AEPs) are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in humans. To assess the potential usefulness of DC-AEPs as an indicator of anesthesia in humans,
Bauer, Herbert, Fitzgerald, Robert, Lamm, Claus, Oczenski, Wolfgang, Stimpfl, Thomas, Vycudilik, Walter   +5 more
core   +1 more source

Phase transitions in biological membranes

, 2018
Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung ...
A Blicher, A Blicher, A Gonzalez-Perez, A Gonzalez-Perez, A Hac, A Punnia-Moorthy, AG Lee, AL Hodgkin, AL Hodgkin, B Lautrup, D Johnston, D Papahadjopoulos, DB Mountcastle, DP Kharakoz, E London, EF DeLong, FH Johnson, FH Johnson, GH Kim, GS Manning, H Ebel, H Kamaya, H Kamaya, H Kamaya, H Träuble, HJ Galla, HM Seeger, HM Seeger, I Tasaki, J Gallaher, J Marmur, JE Rothman, JE Rothman, JLCM Vossenberg van de, JM Ritchie, JR Hazel, JR Hazel, JR Trudell, K Græsbøll, K Iwasa, K Iwasa, K Simons, KA Zecchi, KR Laub, L Onsager, LD Mosgaard, LD Mosgaard, LO Ingram, M Gudmand, M Moldovan, MC Sabra, MJ Halsey, MJ Pringle, OG Mouritsen, P Grabitz, PF Almeida, PL Privalov, R Böckmann, R Ravindra, R Winter, RS Cantor, RS Cantor, RW Glaser, S Johnson, SV Avery, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Horishita, Tian Wang, UR Pedersen, Y Kaminoh, Y Zuo   +76 more
core   +1 more source

Do Complexity Measures of Frontal EEG Distinguish Loss of Consciousness in Geriatric Patients Under Anesthesia? [PDF]

, 2018
While geriatric patients have a high likelihood of requiring anesthesia, they carry an increased risk for adverse cognitive outcomes from its use. Previous work suggests this could be mitigated by better intraoperative monitoring using indexes defined by
Caitlin M. Drover, David R. Drover, Don A. Vaughn, Don A. Vaughn, M. Bruce MacIver, Mark S. Cohen, Mark S. Cohen, Nicholas T. Ouellette, Sarah L. Eagleman   +8 more
core   +2 more sources

Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles

Frontiers in Neurology, 2012
Exposure to general anesthetics and antiepileptics during critical stages of brain development causes significant neurotoxicity to immature neurons.
Vesna eJevtovic-Todorovic, Annalisa eBoscolo, Victoria eSanchez, Nadia eLunardi   +3 more
doaj   +1 more source

Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial. [PDF]

, 2014
UnlabelledAs life expectancy increases, more patients ≥65 years undergo general anesthesia. Anesthetic agents may contribute to postoperative cognitive dysfunction, and incidence may differ with anesthetic agents or intraoperative anesthesia depth ...
Allard, Martin, Anderson, Donald, Applegate, Richard L, Azer, Sherif, Kim, Amy, Mehdizadeh, Ali, Meineke, Minhthy, Rasmussen, Thomas   +7 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source