Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling
Frontiers in Oncology, 2021 Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Chien-shan Cheng
exaly +3 more sources
Editorial: Neural circuits underlying general anesthetics mediated consciousness changes [PDF]
Frontiers in Neural Circuits, 2023 Cheng Zhou
doaj +2 more sources
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance General anesthetics are essential to modern medicine, yet their molecular mechanisms remain poorly understood. Whether general anesthetics primarily act by altering lipid bilayer properties or by interacting directly with specific membrane ...
Herold KF +4 more
europepmc +2 more sources
General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis [PDF]
iScience, 2023 Summary: The cellular and molecular actions of general anesthetics to induce anesthesia state and also cellular signaling changes for subsequent potential “long term” effects remain largely elusive.
Enqiang Chang +26 more
doaj +3 more sources
Characterization of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]
arXiv, 2016 Several experiments provide evidence that specialized brain regions functionally interact and reveal that the brain processes and integrates information in a specific and structured manner. Networks can be applied to model brain functional activities, providing means to characterize and quantify this structured form of organization.
Padovani, Eduardo C.
arxiv +2 more sources
Effect of general anesthetics on the developing brain
Journal of Anaesthesiology Clinical Pharmacology, 2012 Studies on rodents and subhuman primates suggest that prolonged exposure to general anesthetics may induce widespread neuronal cell death and neurological sequelae; seriously questioning the safety of pediatric anesthesia.
S Velayudha Reddy
doaj +4 more sources
General anesthetics inhibit LPS-induced IL-1β expression in glial cells. [PDF]
PLoS ONE, 2013 BACKGROUND: Glial cells, including microglia and astrocytes, are considered the primary source of proinflammatory cytokines in the brain. Immune insults stimulate glial cells to secrete proinflammatory cytokines that modulate the acute systemic response,
Tomoharu Tanaka +5 more
doaj +2 more sources
Atomistic models of general anesthetics for use in in silico biological studies. [PDF]
J Phys Chem B, 2014 While small molecules have been used to induce anesthesia in a clinical setting for well over a century, a detailed understanding of the molecular mechanism remains elusive.
Arcario MJ, Mayne CG, Tajkhorshid E.
europepmc +2 more sources
Characterization of the Community Structure of Large-Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction [PDF]
arXiv, 2016 One of the main goals of neuroscience is to understand how an organism's cognitive capacities or physiological states are potentially related to brain activities that involve the interaction of multiple brain structures and cortical areas. A key feature of functional brain networks is that they are modularly structured, and this modular architecture is
Padovani, Eduardo C.
arxiv +2 more sources
A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. [PDF]
Neuron, 2019 Jiang-Xie LF +6 more
europepmc +2 more sources