Results 81 to 90 of about 4,549,295 (288)
Order conditions for general linear methods
Journal of Computational and Applied Mathematics, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
CARDONE, Angelamaria +3 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Beyond Newtonian Thinking- Towards a Non-linear Archaeology - Applying Chaos Theory to Archaeology
Current Swedish Archaeology, 1997 In this article the authors suggest that chaos theory can provide us with a new perspective on archaeology. Newtonian thinking is predominant in archaeology, as well as in the humanities in general. This results in the hegemony of analytic methods and a
Henrik Gerding, Dominic Ingemark
doaj +1 more source
General linear methods for linear DAEs
, 2005 For linear differential-algebraic equations (DAEs) with properly stated leading terms the property of being numerically qualified guarantees that qualitative properties of DAE solutions are reflected by the numerical approximations. In this case BDF and Runge-Kutta methods integrate the inherent regular ODE.
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Robust optimization model for uncertain multiobjective linear programs
Journal of Inequalities and Applications, 2018 In this paper, we consider the multiobjective linear programs where coefficients in the objective function belong to uncertainty sets. We introduce the concept of robust efficient solutions to uncertain multiobjective linear programming problems.
Lei Wang, Min Fang
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Structural optimisation problem in support to building retrofitting decision [PDF]
, 2005 Various analysis methods, either linear elastic or non-linear, static or dynamic, are available for the performance analysis of existing buildings. Despite its advantages, it must be admitted that non-linear time history analysis can frequently become ...
Costa, A., Pinto, A., Varum, H.
core +1 more source