Results 81 to 90 of about 1,452,737 (303)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
A general Phase-I method in linear programming [PDF]
European Journal of Operational Research, 1986 Phase I of the simplex method finds a basic feasible solution to linear programming (LP) problems. Phase I procedures can also be used for generating feasible points of other problems with linear constraints, or even for checking the consistency of a system of linear equalities/\(inequalities.\) The traditional phase I methods work under the following ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
General Linear Methods with external stages of different orders [PDF]
, 1996 The approach introduced recently by Albrecht to derive order conditions for Runge-Kutta formulas based on the theory of A-methods is also very powerful for the general linear methods.
JACKIEWICZ Z., VERMIGLIO, Rossana
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A generalization of the method of averages for overdetermined linear systems [PDF]
Mathematics of Computation, 1975 Necessary and sufficient conditions are established for an existence and uniqueness result for a generalization of the method of averages for overdetermined linear systems. Some practical schemes are given, and a connection with Galerkin’s method is indicated.
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Beyond Newtonian Thinking- Towards a Non-linear Archaeology - Applying Chaos Theory to Archaeology
Current Swedish Archaeology, 1997 In this article the authors suggest that chaos theory can provide us with a new perspective on archaeology. Newtonian thinking is predominant in archaeology, as well as in the humanities in general. This results in the hegemony of analytic methods and a
Henrik Gerding, Dominic Ingemark
doaj +1 more source
Voting over piece-wise linear tax methods [PDF]
We analyze the problem of choosing the most appropriate method for apportioning taxes in a democracy. We consider a simple theoretical model of taxation and restrict our attention to piece-wise linear tax methods, which are almost ubiquitous in advanced ...
MORENO-TERNERO, Juan D.
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source