Results 91 to 100 of about 18,952,730 (376)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Clinical Distribution Characteristics and Identification for Significant Liver Inflammation of Patients in Chronic Hepatitis B with Indeterminate Phase

Gastroenterology Research and Practice, 2023
Aim. In clinical practice, a considerable proportion of patients with chronic hepatitis B (CHB) who do not conform to any immune status are considered to be in the “indeterminate phase”.
Shanshan Chen, Xuan Dai, Yueyue Zhao, Jie Li, Xuehan Zou, Haijun Huang   +5 more
doaj   +1 more source

INNOVATING FOR GENERAL PRACTICE

Australasian Medical Journal, 2013
This editorial will consider the challenge of innovation for healthcare from three perspectives: the general practitioner (GP), the patient and the policy maker. The knowledge, attitudes and beliefs of each, respectively, are likely to affect the type of innovation adopted in practice. Each stakeholder has priorities and needs that must be reflected in
openaire   +3 more sources

Generic alternatives in general practice. [PDF]

BMJ, 1984
Using a standard analysis of one month's prescribing in a general practice we showed a potential saving of 8.8% (pounds 883.22) of the net cost of ingredients through substituting exact generic alternatives. Our results confirm the possible reduction in cost of drugs to the National Health Service by the use of generic substitution as suggested in the ...
R J Anderson, P M Reilly
openaire   +3 more sources

Trends in sexually transmitted infections in general practice 1990-2000: population based study using data from the UK general practice research database [PDF]

, 2006
Objective: To describe the contribution of primary care to the diagnosis and management of sexually transmitted infections in the United Kingdom, 1990-2000, in the context of increasing incidence of infections in genitourinary medicine clinics ...
Brook, M.G., Cassell, J.A., Hayward, A.C., Hughes, G., Islam, A., Johnson, A.M., Kinghorn, G.R., Majeed, A., Mercer, C.H., Petersen, I., Ross, J.D., Simms, I., Stephenson, J.M., Sutcliffe, L.   +13 more
core  

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Barriers and facilitators to using a web-based tool for diagnosis and monitoring of patients with depression: a qualitative study among Danish general practitioners

BMC Health Services Research, 2018
Background Depression constitutes a significant part of the global burden of diseases. General practice plays a central role in diagnosing and monitoring depression.
Mette Daugbjerg Krog, Marie Germund Nielsen, Jette Videbæk Le, Flemming Bro, Kaj Sparle Christensen, Anna Mygind   +5 more
doaj   +1 more source

The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Respiratory Research, 2020
Background Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism, its single nucleotide ...
Yipeng Ding, Yixiu Yang, Quanni Li, Qiong Feng, Dongchuan Xu, Cibing Wu, Jie Zhao, Xiaoli Zhou, Huan Niu, Ping He, Jianfang Liu, Hongxia Yao   +11 more
doaj   +1 more source

Correlation Analysis between Uric Acid and Metabolic Syndrome in the Chinese Elderly Population: A Cross-Sectional Study

International Journal of Endocrinology, 2023
Background. Currently, both metabolic syndrome and hyperuricaemia have attracted extensive attention in public health. The correlation between uric acid and metabolic syndrome is controversial. Research on the relationship between uric acid and metabolic
Guqiao Nie, Jing jing Wan, Lei Jiang, Shu kai Hou, Wen Peng   +4 more
doaj   +1 more source

An integrative review of facilitators and barriers influencing collaboration and teamwork between general practitioners and nurses working in general practice.

Journal of Advanced Nursing, 2015
AIM To identify facilitators and barriers influencing collaboration and teamwork between general practitioners and nurses working in general (family) practice. BACKGROUND Internationally, a shortage of doctors entering and remaining in general practice
Susan Mcinnes, K. Peters, Andrew D Bonney, E. Halcomb   +3 more
semanticscholar   +1 more source