Results 91 to 100 of about 8,081,518 (357)

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
A Donner, AJ Bellg, AJ Engers, Australian Acute Musculoskeletal Pain Guidelines Group (AAMPGG), B McGuirk, BF Walker, BF Walker, BS Frankel, C Bombardier, C Bombardier, D Di Iorio, D Mortimer, Denise A O'Connor, DG Altman, DG Altman, DK Freeborn, Duncan Mortimer, DW King, DW King, EM Hay, FB Hu, G Waddell, GM Fitzmaurice, H Britt, H Schers, J Francis, J Mollison, J Zhang, Jeremy M Grimshaw, Jill Francis, JJ Yallop, JM Grimshaw, JM Neuhaus, JM Schectman, Joanne E McKenzie, M Campbell, M Eccles, M Roland, M Roland, M Von Korff, MK Campbell, MR Robling, N Klar, Neil Spike, NJ Horton, OC Ukoumunne, P Dey, P Little, P Oakeshott, PB Bishop, Peter M Kent, Peter Schattner, PJ Diggle, PM Kent, R Buchbinder, R Buchbinder, R Buchbinder, R Buchbinder, R Grol, Rachelle Buchbinder, S Hakkennes, S Hollis, S Kerry, S Michie, Sally E Green, Simon D French, SJ Pocock, SJ Senn, SR Heritier, Susan Michie, SZ George, T Permutt, TS Carey, V Gonzalez-Urzelai, W Hardeman   +74 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

High-performing primary care: reinvigorating general practice as a learning health system [PDF]

, 2022
Darran Foo, Janani Mahadeva, Francisco Lopez, Louise A. Ellis, Kate Churruca, Genevieve Dammery, Simon Willcock, Jeffrey Braithwaite   +7 more
openalex   +1 more source

Trends in HIV testing and recording of HIV status in the UK primary care setting: a retrospective cohort study 1995-2005 [PDF]

, 2009
Objectives: To provide nationally representative data on trends in HIV testing in primary care and to estimate the proportion of diagnosed HIV positive individuals known to general practitioners (GPs).
Brook, G, Cassell, Jackie A., Chadborn, T., Delpech, V., Evans, H.E.R., Hamill, M., Hughes, G., Johnson, A.M., Mercer, C.H., Petersen, I., Rait, G., Singh, S., Williams, T.   +12 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The impact of COVID-19 on electronic repeat dispensing (eRD) in general practice [PDF]

, 2023
Raman Sharma, Farideh Javid
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

General practice workload [PDF]

British Journal of General Practice, 2016
Des seems to have been working in an alternative universe of general practice.1 Numerous pressures from outside general practice control have driven up workload. Computers have allowed identification of all of one’s patients to be tested, checked, and ripened for preventive medication. Chronic disease …
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Development of a PROM to measure patient-centredness in chronic care consultations in primary care

Health and Quality of Life Outcomes
Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often ...
Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group   +15 more
doaj   +1 more source