Results 101 to 110 of about 8,118,969 (359)

A cross sectional study of water quality from dental unit water lines in dental practices in the West of Scotland [PDF]

, 2002
OBJECTIVE: To determine the microbiological quality of water from dental units in a general practice setting and current practice for disinfection of units. DESIGN: A cross-sectional study of the water quality from 40 dental units in 39 general practices
A Gross, A J Smith, A McMillan, C Paszko-Kovla, CL Pankhurst, CL Pankhurst, GC Blake, HN Williams, HN Williams, J Hood, JT Walker, L McCormick, MV Martin, R Stansfield, RC Scheid, RC Scheid, RLS Whitehouse, RM Atlas, S McHugh, SJ Challacombe   +19 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Trends in HIV testing and recording of HIV status in the UK primary care setting: a retrospective cohort study 1995-2005 [PDF]

, 2009
Objectives: To provide nationally representative data on trends in HIV testing in primary care and to estimate the proportion of diagnosed HIV positive individuals known to general practitioners (GPs).
Brook, G, Cassell, Jackie A., Chadborn, T., Delpech, V., Evans, H.E.R., Hamill, M., Hughes, G., Johnson, A.M., Mercer, C.H., Petersen, I., Rait, G., Singh, S., Williams, T.   +12 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

General practice workload [PDF]

British Journal of General Practice, 2016
Des seems to have been working in an alternative universe of general practice.1 Numerous pressures from outside general practice control have driven up workload. Computers have allowed identification of all of one’s patients to be tested, checked, and ripened for preventive medication. Chronic disease …
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Development of a PROM to measure patient-centredness in chronic care consultations in primary care

Health and Quality of Life Outcomes
Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often ...
Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group   +15 more
doaj   +1 more source

Barriers and facilitators to using a web-based tool for diagnosis and monitoring of patients with depression: a qualitative study among Danish general practitioners

BMC Health Services Research, 2018
Background Depression constitutes a significant part of the global burden of diseases. General practice plays a central role in diagnosing and monitoring depression.
Mette Daugbjerg Krog, Marie Germund Nielsen, Jette Videbæk Le, Flemming Bro, Kaj Sparle Christensen, Anna Mygind   +5 more
doaj   +1 more source

Circuits of power : a study of the development of computer software and its use in general medical practice : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Sociology at Massey University [PDF]

, 2000
This thesis explores several phases in the life history of a software package developed in New Zealand for the primary healthcare market in order to show how the package is implicated in maintaining or changing existing distributions of power.
Cornford, Elizabeth Phillipa
core