Results 111 to 120 of about 8,081,518 (357)

MDT Reduces Perioperative Thrombotic Events in Elderly Orthopedic Patients

Journal of Multidisciplinary Healthcare
Tonghua Chen,1,* Xiaojun Lei,1,* Jingwei Tian,1,* Haochen Mai,1 Yuanfang Yu,1 Wenxia Wu,1 Liqiang Wen,1 Phei Er Saw,1 Meng Zhang1,2 1Department of General Practice, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou,
Chen T, Lei X, Tian J, Mai H, Yu Y, Wu W, Wen L, Saw PE, Zhang M   +8 more
doaj  

Use of a primary care online consultation system, by whom, when and why: evaluation of a pilot observational study in 36 general practices in South West England [PDF]

, 2017
Hannah B Edwards, Elsa Marques, William Hollingworth, Jeremy Horwood, Michelle Farr, Elly Bernard, Chris Salisbury, Kate Northstone   +7 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Interpretable Machine Learning Model for Predicting 1-Year Unplanned Readmissions in Ischemic Stroke Patients with Diabetes: A Synergistic View of Inflammation and Metabolism

Clinical Interventions in Aging
Yue Hu,1,* Yunhong Zhang,2,* Peichong Lin,3,4,* Xinye Hu,5 Yiping Zhu,6 Peiling Yan,7 Fan Fei,8 Qiuyan Wang,9 Xuelin Yao,10 Jingjing Ren1 1Department of General Practice, the First Affiliated Hospital, Zhejiang University School ...
Hu Y, Zhang Y, Lin P, Hu X, Zhu Y, Yan P, Fei F, Wang Q, Yao X, Ren J   +9 more
doaj  

Benefits of Community-based Treatment for Patients with Schizophrenia: Based on Long-acting Injectable Antipsychotic Agents [PDF]

Zhongguo quanke yixue
Schizophrenia could affect the social and occupational functions of patients in the long term. Community-based mental health services and management models promote mental health by improving accessibility, acceptability, affordability, practicality and ...
Schizophrenia Coordination Group, Chinese Society of Psychiatry, Chinese Society of General Practice, LI Qian, SI Tianmei
doaj   +1 more source

Antibiotic prescribing for common infections in UK general practice: variability and drivers [PDF]

, 2019
Victoria Palin, Anna Mölter, Miguel Belmonte, Darren M. Ashcroft, Andrew White, William Welfare, Tjeerd van Staa   +6 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Implementation and acceptability of the Caregiver Care Model in general practice: a mixed-method feasibility study

BMC Primary Care
Background Being a caregiver can be demanding. Therefore, we developed the Caregiver Care Model for general practice. The model consists of a mandatory dialogue questionnaire, which is used to identify support needs in caregivers, grief-facilitating ...
Mette Kjaergaard Nielsen, Marie Cecilie Vinther, Mai-Britt Guldin, Kaj Sparle Christensen, Anna Mygind   +4 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source