Results 111 to 120 of about 8,118,969 (359)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus

Journal of Diabetes Research
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion. Immune dysregulation-mediated chronic low-grade inflammation is a critical factor
Wei Zheng, Xin Ji, Qiao qiao Yin, Chensi Wu, Chengan Xu, Hongying Pan, Chun Wu   +6 more
doaj   +1 more source

Continuity in general practice and hospitalization patterns: an observational study [PDF]

, 2021
Michel Wensing, Joachim Szécsényi, Gunter Laux   +2 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

‘I’ve put diabetes completely on the shelf till the mental stuff is in place’. How patients with doctor-assessed impaired self-care perceive disease, self-care, and support from general practitioners. A qualitative study

Scandinavian Journal of Primary Health Care, 2018
Objective: This paper investigated patients’ experiences of disease and self-care as well as perceptions of the general practitioner’s role in supporting patients with impaired self-care ability.
Mads Aage Toft Kristensen, Ann Dorrit Guassora, Anne Beiter Arreskov, Frans Boch Waldorff, Bibi Hølge-Hazelton   +4 more
doaj   +1 more source

Promoting Mental Health and Preventing Mental Illness in General Practice [PDF]

, 2016
Stephen Thomas, Rachel Jenkins, Tony Burch, Laura Nasir, Brian Fisher, Gina Giotaki, Shamini Gnani, Lise Hertel, Marina Marks, Nigel Mathers, Catherine Millington‐Sanders, David Morris, Baljeet Ruprah-Shah, Kurt C. Stange, Paul Thomas, Robert D. White, Fiona Wright   +16 more
openalex   +1 more source

Managing medically unexplained illness in general practice [PDF]

Provides practical management strategies that general practitioners (GPs) can use when patients present with medically unexplained symptoms. Background Patients with medically unexplained symptoms commonly present to general practice and experience ...
Louise Stone
core  

Integrated out-of-hours care arrangements in England: observational study of progress towards single call access via NHS Direct and impact on the wider health system [PDF]

, 2005
Objectives: To assess the extent of service integration achieved within general practice cooperatives and NHS Direct sites participating in the Department of Health’s national “Exemplar Programme” for single call access to out-of-hours care via NHS ...
Burgess, A, George, S, Gerard, K, Lathlean, J, Lattimer, V, Smith, H, Surridge, H, Turnball, J   +7 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Interpretable Machine Learning Model for Predicting 1-Year Unplanned Readmissions in Ischemic Stroke Patients with Diabetes: A Synergistic View of Inflammation and Metabolism

Clinical Interventions in Aging
Yue Hu,1,* Yunhong Zhang,2,* Peichong Lin,3,4,* Xinye Hu,5 Yiping Zhu,6 Peiling Yan,7 Fan Fei,8 Qiuyan Wang,9 Xuelin Yao,10 Jingjing Ren1 1Department of General Practice, the First Affiliated Hospital, Zhejiang University School ...
Hu Y, Zhang Y, Lin P, Hu X, Zhu Y, Yan P, Fei F, Wang Q, Yao X, Ren J   +9 more
doaj