Results 121 to 130 of about 2,657,945 (266)

Relationally competent attitudes and actions: a systematic review of general practice literature

open access: yesScandinavian Journal of Primary Health Care
Objective To explore core elements from Teachers’ Relational Competence in general practice literature regarding building relationships in consultations, specifying actions doctors take to create and maintain relationship quality with patients.
Cæcilie Hansen   +4 more
doaj   +1 more source

Understanding Growth Mindset Practices in an Introductory Physical Computing Classroom: High School Students' Engagement with Debugging by Design Activities [PDF]

open access: yesarXiv
Background and Context: While debugging is recognized as an essential practice, for many students, encountering bugs can generate emotional responses such as fear and anxiety that can lead to disengagement and the avoidance of computer programming.
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Best Practices for Developing Computational and Data-Intensive (CDI) Applications [PDF]

open access: yesarXiv
High-quality computational and data-intensive (CDI) applications are critical for advancing research frontiers in almost all disciplines. Despite their importance, there is a significant gap due to the lack of comprehensive best practices for developing such applications. CDI projects, characterized by specialized computational needs, high data volumes,
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

Hydrogen sulfide repairs testicular damage induced by heat stress in rats

open access: yesFEBS Open Bio, EarlyView.
Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo   +6 more
wiley   +1 more source

Detection of atrial fibrillation using a nonlinear Lorenz Scattergram and deep learning in primary care

open access: yesBMC Primary Care
Background Atrial fibrillation (AF) is highly correlated with heart failure, stroke and death. Screening increases AF detection and facilitates the early adoption of comprehensive intervention.
Yi Yao   +8 more
doaj   +1 more source

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