Results 131 to 140 of about 18,952,730 (376)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, Volume 19, Issue 7, Page 2120-2132, July 2025.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Prevalence of comorbid depression and obesity in general practice: a cross-sectional survey

The British journal of general practice : the journal of the Royal College of General Practitioners, 2014
Background General practice is a common setting for the provision of weight-management advice, as well as the treatment of depression. While there is some evidence of a reciprocal relationship between obesity and depression, there are limited data about ...
M. Carey, H. Small, S. Yoong, A. Boyes, A. Bisquera, R. Sanson-Fisher   +5 more
semanticscholar   +1 more source

ERGOT IN GENERAL PRACTICE. [PDF]

JAMA: The Journal of the American Medical Association, 1904
The chief object of this paper is to demonstrate that inefficient tone of unstriated muscular fiber is a common and serious element of disease; and that it is important to guard against, or to correct, such abnormal state of that tissue. The secondary object is to show that a drug which has been used therapeutically for three centuries for a single ...
openaire   +3 more sources

Management in General Practice - 3: A slelection of articles [PDF]

, 1992
A selection of articles published in the medical journal Pulse in ...
Burns, Paul, Harrison, Jean
core  

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, Volume 19, Issue 7, Page 2038-2055, July 2025.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Systems and Complexity Thinking in the General Practice Literature: An Integrative, Historical Narrative Review

Annals of Family Medicine, 2014
PURPOSE Over the past 7 decades, theories in the systems and complexity sciences have had a major influence on academic thinking and research. We assessed the impact of complexity science on general practice/family medicine.
J. Sturmberg, Carmel M Martin, D. Katerndahl   +2 more
semanticscholar   +1 more source

Prediction of depression in European general practice attendees: the PREDICT study [PDF]

, 2006
Background Prevention of depression must address multiple risk factors. Estimating overall risk across a range of putative risk factors is fundamental to prevention of depression. However, we lack reliable and valid methods of risk estimation.
Aluoja, Anu, Bellón-Saameño, Juan A., Caldas de Almeida, Manuel, Carraça, Idalmiro, Geerlings, Mirjam I., Kalda, Ruth, King, Michael, Maaroos, Heidi-Ingrid, Moreno-Küstner, Berta, Morris, Richard, Nazareth, Irwin, Neeleman, Jan, Rifel, Janez, Rioseco, Pedro, Rotar, Danica, Saldivia, Sandra, Torres-González, Francisco, Vicente, Benjamin, Walker, Carl, Weich, Scott, Xavier, Miguel, Švab, Igor   +21 more
core   +10 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Effectiveness of general practice-based health checks: a systematic review and meta-analysis.

The British journal of general practice : the journal of the Royal College of General Practitioners, 2014
BACKGROUND A recent review concluded that general health checks fail to reduce mortality in adults. AIM This review focuses on general practice-based health checks and their effects on both surrogate and final outcomes.
S. Si, J. Moss, T. Sullivan, S. Newton, N. Stocks   +4 more
semanticscholar   +1 more source

Male frequent attenders of general practice and their help seeking preferences [PDF]

, 2011
Background: Low rates of health service usage by men are commonly linked to masculine values and traditional male gender roles. However, not all men conform to these stereotypical notions of masculinity, with some men choosing to attend health services ...
Adshead F., Alan K. White, Anne-Marie Bagnall, Corney R.H., Courtenay W.H., Galdas P.M., George A., Green C.A., Harrison A., Heywood P., Jane South, Karl R. Witty, Macintyre S., Möller-Leimkühler A.M., Noone J.H., Randall M., Robertson S., Scaife B., Shalev V., Shapiro S., Smith J.A., Smith J.A., Smith J.A., Vedsted P., Wilkins D.   +24 more
core   +1 more source