Results 91 to 100 of about 6,369,263 (335)

Hydrology and Hydraulic Analysis of Nasiri Flash Flood Disaster Event on the 1st August 2012

open access: yesJournal of the Civil Engineering Forum, 2018
Nasiri lays in the Luhu village, Huamual district, West Seram Regency, Maluku province. Nasiri experienced in flash flood on August 1st, 2012 which had never happened before. There was no rainfall station and water level recorder at that time.
Imam Syarif Hidayatulloh   +2 more
doaj   +1 more source

Private-Law Models for Official Immunity [PDF]

open access: yes, 1978
A method for correcting matching errors in an ADC is presented. The method uses the unknown input data from the application and does not require any test signal. Two algorithms for implementing the method are compared.
Eklund, Jan-Erik, Elbornsson, Jonas
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

A Comparative Study of the General Health among Staff Nurses with Fixed or Rotating Working Shift

open access: yesنشریه پرستاری ایران, 2007
Introduction and Aim: Long time working shifts and its related tiredness threatens the health of staff nurses in various dimensions. If nurses don’t experience a good general health, they would not be able to deliver good patient care.
M .A. Soleimany   +3 more
doaj  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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