Results 51 to 60 of about 1,082,405 (237)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Robust Trajectory Tracking for Omnidirectional Mobile Robots with Input Time Delay: An ADRC Approach

Mathematics
In this article, the problem of control of the kinematic model of an omnidirectional robot with time delay in the control input is tackled through an Active Disturbance Rejection Control (ADRC) with a disturbance predictor-based scheme, which consists in
Alberto Luviano-Juárez, Mario Ramírez-Neria, Jaime González-Sierra   +2 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Robust Adaptive Generalized Projective Synchronization of Chaotic Systems with Uncertain Disturbances

Journal of Applied Mathematics, 2012
The generalized projective synchronization (GPS) of chaotic systems with uncertain parameter noise and external disturbance is discussed. Based on the adaptive technique, a response system is constructed, and a novel adaptive controller is designed to ...
Zhen Jia, Guangming Deng
doaj   +1 more source

The long-term consequences of short-term responses to disturbance: Experiences from whalewatching impact assessment [PDF]

, 2007
Studies often use behavioral responses to detect the impact of given disturbances on animals. However, the observation of these short-term responses can often lead to contradicting results.
Bejder, Lars, Lusseau, D., Lusseau, David, Bejder, L.   +3 more
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Embedded Model Control calls for disturbance modeling and rejection [PDF]

, 2012
Robust control design is mainly devoted to guaranteeing the closed-loop stability of a model-based control law in the presence of parametric uncertainties.
Perez, C., MOLANO JIMENEZ, ANDRES GUILLERMO, Canuto, Enrico, Acuna Bravo, Wilber, Molano, A., PEREZ MONTENEGRO, CARLOS NORBERTO   +5 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Assessing conservation of a tropical African estuary : waterbird disturbance, livelihoods, and ecotourism [PDF]

, 2011
The aim of this study was to evaluate the potential costs and benefits of increasing conservation in the Sabaki River Mouth Important Bird Area. This was achieved by assessing the vulnerability of waterbirds to disturbance from human activity in the ...
England, Kate
core   +1 more source