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Complete lesion resection and early surgical intervention are favorable factors for long‐term seizure freedom in drug‐resistant epileptic spasms

Epilepsia Open, EarlyView.
Abstract Objective Epileptic spasms (ES) in children carry a high risk of neurodevelopmental delay, yet predictors of long‐term surgical outcome remain incompletely defined. This study aimed to evaluate seizure outcomes following epilepsy surgery and to identify independent prognostic factors for postoperative recurrence.
Hua Li, Yao Wang, Qiang Guo, Junxi Chen, Kaihui Li, Danfang Li, Qinghua Tan, Jing Guo   +7 more
wiley   +1 more source

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Anticonvulsant drugs for generalized tonic-clonic epilepsy

Expert Opinion on Pharmacotherapy, 2017
Primary generalized tonic clonic seizures (pGTCS) are still linked to major concerns for the clinic and hazards for patients suffering from idiopathic generalized epilepsy (IGE), so a quick search of the most effective and appropriate therapy is needed to control them.
Alberto Verrotti, Francesca Operto, Giangennaro Coppola   +2 more
exaly   +4 more sources

Photoplethysmographic evaluation of generalized tonic‐clonic seizures

Epilepsia, 2020
AbstractObjectivePhotoplethysmography (PPG) is an optical technique measuring variations of blood perfusion in peripheral tissues. We evaluated alterations in PPG signals in relationship to the occurrence of generalized tonic‐clonic seizures (GTCSs) in patients with epilepsy to evaluate the feasibility of seizure detection.MethodsDuring ...
Fatemeh Mohammadpour Touserkani, Eleonora Tamilia, Francesca Coughlin, Sarah Hammond, Rima El Atrache, Michele Jackson, Megan Bendsen‐Jensen, Boram Kim, Jack Connolly, Sheryl Manganaro, Christos Papadelis, Kush Kapur, Tobias Loddenkemper   +12 more
openaire   +2 more sources

Generalized Tonic and Tonic-Clonic Seizures of Childhood

Journal of Child Neurology, 1998
In a retrospective analysis of all our patients with seizure onset prior to age 16 years, 25 patients with primary generalized tonic (n = 10) or tonic-clonic (n = 15) seizures were identified. These patients constituted 5.7% of the total seizure patient population in our institute between the ages of 1 month and 16 years.
U, Kramer, Y, Nevo, L, Yael, S, Harel
openaire   +2 more sources

Generalized Tonic–Clonic Seizures

2013
Generalized tonic–clonic seizures (GTCs) have long been assumed to produce their dramatic clinical effects through a widely distributed and uniform dysfunction of the human cerebral cortex. However, evidence from a diversity of sources is mounting that GTCs actually exert their influence through discrete cortical and subcortical brain areas, while ...
Paige AL, Cavanna A
openaire   +1 more source

The secondarily generalized tonic‐clonic seizure

Neurology, 1994
We studied 120 generalized tonic-clonic seizures (GTCSs) in 47 patients with video-EEG telemetry. GTCSs were preceded by antecedent seizures, including 13 simple partial, 70 complex partial, 17 simple partial leading to complex partial, seven tonic, seven clonic, and one typical absence.
W H, Theodore, R J, Porter, P, Albert, K, Kelley, E, Bromfield, O, Devinsky, S, Sato   +6 more
openaire   +2 more sources

THE HORMONAL RESPONSES TO GENERALIZED TONIC-CLONIC SEIZURES

Brain, 1984
We studied the hormonal responses to a generalized tonic-clonic convulsion in 20 patients with idiopathic or posttraumatic epilepsy (6 patients) or alcohol-withdrawal seizures (14 patients). We found an increase shortly after the seizure in plasma levels of ACTH, beta endorphin, beta lipotropin, prolactin, and vasopressin, and a later increase in ...
M J, Aminoff, R P, Simon, E, Wiedemann
openaire   +2 more sources

Generalized Tonic-Clonic Epilepsies

1987
This chapter focuses on generalized tonic-clonic seizures, including both those of nonfocal origin (primarily generalized tonic-clonic seizures) and those generalized by propagation from a lateralized or restricted cortical area (secondarily generalized tonic-clonic seizures).
Bruce J. Fisch, Timothy A. Pedley
openaire   +1 more source

Generalized Tonic–Clonic and Febrile Seizures

Pediatric Clinics of North America, 1989
In general, children with febrile seizures have a good prognosis, and only a small minority of children go on to become epileptic. Most outgrow the tendency to have seizures, and the seizures do not appear to cause lasting intellectual or neurologic damage.
openaire   +2 more sources